Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

The Journal of Allergy and Clinical Immunology
Xiaoguang SunJoe G N Garcia

Abstract

The genetic mechanisms underlying asthma remain unclear. Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation. We explored the contribution of polymorphisms in the S1PR1 gene to asthma susceptibility. A combination of gene resequencing for single nucleotide polymorphism (SNP) discovery, case-control association, functional evaluation of associated SNPs, and protein immunochemistry studies was used. Immunohistochemistry studies demonstrated significantly decreased S1PR1 protein expression in pulmonary vessels in lungs of asthmatic patients compared with those of nonasthmatic subjects (P < .05). Direct DNA sequencing of 27 multiethnic samples identified 39 S1PR1 variants (18 novel SNPs). Association studies were performed based on genotyping results from cosmopolitan tagging SNPs in 3 case-control cohorts from Chicago and New York totaling 1,061 subjects (502 cases and 559 control subjects). The promoter SNP rs2038366 (-1557G/T) was found to be associated with asthma (P = .03) in European Americans. In African Americans an association was found for both asthma and sev...Continue Reading

References

Dec 1, 1995·American Journal of Respiratory Cell and Molecular Biology·I OhnoG Tamura
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·M AmishimaY Kawakami
Aug 7, 1998·Genomics·S E Antonarakis
Dec 5, 1998·American Journal of Human Genetics·E J ParraM D Shriver
Feb 10, 1999·The American Journal of Physiology·V P KrymskayaR A Panettieri
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·E T NaureckasJ Solway
May 29, 2000·American Journal of Human Genetics·J K PritchardP Donnelly
Jul 6, 2000·International Archives of Allergy and Immunology·T Baumruker, E E Prieschl
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D EnglishJ G Garcia
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J AmmitR A Panettieri
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·L A LesterUNKNOWN Collaborative Study on the Genetics of Asthma
Nov 21, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I H MeyerJ G Ford
Oct 10, 2002·The Journal of Allergy and Clinical Immunology·Kazuhisa AsaiJunichi Yoshikawa
Apr 22, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eric M BreyCharles W Patrick
May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ana Paula V DantasThomas Michel
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junsuke IgarashiThomas Michel
Mar 17, 2004·American Journal of Respiratory and Critical Care Medicine·Xinqi PengJoe G N Garcia
Mar 27, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi KanazawaJunichi Yoshikawa
Jun 8, 2004·The Journal of Biological Chemistry·Hervé Le StunffSarah Spiegel
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Bryan J McVerryJoe G N Garcia
Sep 7, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gene R PesolaJean G Ford
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick A SingletonJoe G N Garcia
Mar 28, 2006·Current Opinion in Pharmacology·Volker Brinkmann, Thomas Baumruker
May 10, 2006·Nature Genetics·Laufey T AmundadottirKari Stefansson
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Thorsten KurzCarole Ober
Nov 3, 2006·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Dec 14, 2006·European Journal of Human Genetics : EJHG·Keyue Ding, Iftikhar J Kullo
Feb 27, 2007·American Journal of Respiratory Cell and Molecular Biology·Fiorentina RoviezzoGiuseppe Cirino

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Citations

May 7, 2011·Nature Reviews. Immunology·Sarah Spiegel, Sheldon Milstien
Jul 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Xiaoguang SunJoe G N Garcia
Jan 12, 2012·PloS One·Carlos FloresJoe G N Garcia
May 6, 2011·Proceedings of the American Thoracic Society·Joe G N Garcia
Jan 3, 2012·Paediatric Respiratory Reviews·Kimberly Danieli Watts
Dec 18, 2010·Pediatric Annals·Kimberly Danieli Watts, Michael S Schechter
Dec 8, 2015·Molecular and Cellular Pediatrics·Jennie G OnoStefan Worgall
May 31, 2015·The Journal of Allergy and Clinical Immunology·Marialbert Acosta-HerreraCarlos Flores
Jun 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Marialbert Acosta-HerreraUNKNOWN GRECIA and GEN-SEP networks
Mar 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina MillerDavid H Broide
Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Audrey PoonCatherine Laprise
Dec 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ting WangStephen M Black
Mar 7, 2020·American Journal of Respiratory Cell and Molecular Biology·Xiaoguang SunJoe G N Garcia
Jun 27, 2020·Expert Opinion on Therapeutic Targets·Michiel Langeslag, Michaela Kress
Aug 6, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaoguang SunJoe G N Garcia
Oct 14, 2017·American Journal of Respiratory and Critical Care Medicine·Arunabh TalwarUNKNOWN Pulmonary Circulation Assembly
Dec 18, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric EngelbrechtTimothy Hla
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Stanley J Szefler

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