Functional venomics of the Sri Lankan Russell's viper (Daboia russelii) and its toxinological correlations

Journal of Proteomics
Nget Hong TanChoo Hock Tan

Abstract

The venom proteome (venomics) of the Sri Lankan Daboia russelii was elucidated using 1D SDS PAGE nano-ESI-LCMS/MS shotgun proteomics. A total of 41 different venom proteins belonging to 11 different protein families were identified. The four main protein families are phospholipase A2 (PLA2, 35.0%), snaclec (SCL, 22.4%, mainly platelet aggregation inhibitors), snake venom serine proteinase (SVSP, 16.0%, mainly Factor V activating enzyme) and snake venom metalloproteinase (SVMP, 6.9%, mainly heavy chain of Factor X activating enzyme). Other protein families that account for more than 1% of the venom protein include l-amino acid oxidase (LAAO, 5.2%), Kunitz-type serine proteinase inhibitor (KSPI, 4.6%), venom nerve growth factor (VNGF. 3.5%), 5'-nucleotidase (5'NUC, 3.0%), cysteine-rich secretory protein (CRISP, 2.0%) and phosphodiesterase (PDE, 1.3%). The venom proteome is consistent with the enzymatic and toxic activities of the venom, and it correlates with the clinical manifestations of Sri Lankan D. russelii envenomation which include hemorrhage, coagulopathy, renal failure, neuro-myotoxicity and intravascular hemolysis. The venom exhibited remarkable presypnatic neurotoxicity presumably due to the action of basic PLA2 in hig...Continue Reading

References

Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·B J WoodhamsR A Hutton
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·G P Jayanthi, T V Gowda
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·A W BernheimerK S Kim
Jun 1, 1995·Toxicon : Official Journal of the International Society on Toxinology· Tun-Pe Khin-Aung-Cho
Jan 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·I H TsaiJ C Su
Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Francine G SerafimMarcos D Fontana
May 16, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·R R J ShelkeT V Gowda
Apr 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R Borja-OliveiraL Rodrigues-Simioni
Feb 24, 1964·Biochimica Et Biophysica Acta·E CONDREAJ MAGER
Aug 11, 2004·Toxicon : Official Journal of the International Society on Toxinology·Yasuo Yamazaki, Takashi Morita
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Katrin TrummalJüri Siigur
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Solange M T Serrano, Rachid C Maroun
Dec 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Shu-Rong ZhongYun Zhang
May 17, 2007·Acta Crystallographica. Section D, Biological Crystallography·Gayathri GopalanKunchithapadam Swaminathan
Nov 6, 2007·Current Pharmaceutical Design·Kenneth J ClemetsonJeannine M Clemetson
Jun 6, 2009·Cellular and Molecular Life Sciences : CMLS·R Doley, R M Kini
Jun 16, 2009·Toxicon : Official Journal of the International Society on Toxinology·Shu-Rong ZhongQiu-Min Lu
Jul 21, 2009·Journal of Pharmacological and Toxicological Methods·Margaret A O'Leary, Geoffrey K Isbister
Aug 20, 2009·Protein and Peptide Letters·Juliana P ZulianiRodrigo G Stabeli
Mar 25, 2010·Biochemistry. Biokhimii︠a︡·B L Dhananjaya, C J M D Souza
Jun 7, 2011·Toxicon : Official Journal of the International Society on Toxinology·Pattadon SukkapanJohn C Pérez
Jun 28, 2011·Toxicon : Official Journal of the International Society on Toxinology·Montamas SuntravatIssarang Nuchprayoon
Aug 30, 2011·FEBS Letters·Daisuke NakayamaSoichi Takeda
Nov 24, 2011·Toxicon : Official Journal of the International Society on Toxinology·Camila RenjifoAlain Riveros
Dec 6, 2012·Toxicon : Official Journal of the International Society on Toxinology·Vijayabala JeevaganDavid A Warrell
Jan 5, 2013·Toxicon : Official Journal of the International Society on Toxinology·Chun-teng GuoAnthony J Bjourson
Feb 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Carmel M BarberWayne C Hodgson
Nov 12, 2013·Journal of Proteomics·Bruno LomonteJuan J Calvete
Jun 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·Jyotirmoy Mitra, Debasish Bhattacharyya
Jul 15, 2015·Toxicon : Official Journal of the International Society on Toxinology·Maitreyee SharmaRobin Doley

❮ Previous
Next ❯

Citations

Mar 1, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anjana SilvaGeoffrey K Isbister
Dec 3, 2016·PLoS Neglected Tropical Diseases·Anjana SilvaGeoffrey K Isbister
Dec 26, 2016·Biochimica Et Biophysica Acta. General Subjects·Johara Boldrini-FrançaEliane Candiani Arantes
Sep 21, 2017·Toxins·Theo Tasoulis, Geoffrey K Isbister
Nov 2, 2018·Scientific Reports·Alexandra RucavadoJay W Fox
Jan 21, 2017·Journal of Thrombosis and Haemostasis : JTH·G K IsbisterN A Buckley
May 4, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Bruno Lomonte, Juan J Calvete
Feb 23, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Thava Malar Changra LingamChoo Hock Tan
Oct 28, 2019·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Khin Than Yee, Ponlapat Rojnuckarin
Oct 31, 2020·International Journal of Biological Macromolecules·Chunlin YuPengcheng Li
Aug 12, 2020·Toxicon : Official Journal of the International Society on Toxinology·Alexandra RucavadoJay W Fox
Mar 31, 2021·Wilderness & Environmental Medicine·Maya GopalakrishnanMahendra Kumar Garg
Oct 21, 2017·Toxicon : Official Journal of the International Society on Toxinology·Choo Hock TanVisith Sitprija

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.