Functionality study of santalin as tyrosinase inhibitor: A potential depigmentation agent

International Journal of Biological Macromolecules
Hemachandran HridyaRamamoorthy Siva

Abstract

Excessive melanin production leads to hyperpigmentation disorders which results in distressing aesthetic values. Though there are some synthetic depigmentation agents available it has been reported to possess cytotoxic and mutagenic effects. Hence there is a need for the development of safe and non toxic natural tyrosinase inhibitors. Here we report the role of santalin, the chief constituent of Pterocarpus santalinus in inhibition of tyrosinase and melanin synthesis. Santalin inhibited tyrosinase activity dose dependently. Inhibitory kinetic studies revealed mixed type of inhibition with reversible mechanism. Santalin was found to interact with the fluorophore amino acid residue of tyrosinase. Analysis of circular dichroism spectra showed the binding of santalin to tyrosinase which induced the loss of secondary helical structure. Molecular docking result suggested that santalin interact with the catalytic core of tyrosinase through strong hydrogen and hydrophobic bonding. The results of in vitro studies showed santalin inhibited melanogenesis through down regulation of MITF, tyrosinase, TRP-1 and TRP-2 without any cytotoxic effects towards B16F0 melanoma cells. Therefore, our results suggested that santalin possesses anti-tyro...Continue Reading

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Citations

Jul 1, 2017·Journal of Biomolecular Structure & Dynamics·Sankari MohanSiva Ramamoorthy
Mar 27, 2020·Frontiers in Pharmacology·Jianmin ChenNan Jin
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nurshafika Mohd SakehSyahida Ahmad
Dec 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·EunJin BangHae Young Chung
Apr 25, 2019·MedChemComm·Katarzyna Hałdys, Rafał Latajka
Oct 28, 2021·Journal of Agricultural and Food Chemistry·Haixia XuGuanglei Zhao

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