Abstract
Bisphosphonates (BPs) are widely employed for the treatment of a variety of bone disorders. We have previously successfully added small amounts of BPs into calcium phosphate bone cements in order to enhance their bio-functionality. In this work we were able to increase greatly the amount of BP introduced in the cement, thanks to suitable modifications of composition. In particular, we utilized biomimetic alpha-tricalcium phosphate (alpha-TCP) cements at different gelatin contents (10, 15 and 20 wt.%) to introduce Disodium Alendronate up to a concentration of 25 mM. Due to the small liquid/powder ratio (0.22 ml/g) the lengthening of the setting times due to alendronate is quite modest. The rate of transformation of alpha-TCP into calcium deficient hydroxyapatite slightly decreases as a function of alendronate content, whereas it increases with increasing gelatin concentration. Moreover, relatively high alendronate concentrations provoke significant reduction of the compressive strength of the cements. The results of in vitro tests indicate that alendronate-containing cements significantly affect osteoclast proliferation and differentiation, whereas they promote osteoblast differentiation, to an extent which depends on cement com...Continue Reading
Citations
Feb 21, 2014·Journal of Materials Science. Materials in Medicine·M SartoriM Fini
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Zhonghua ShenJiandong Ye
Aug 2, 2012·Journal of Materials Science. Materials in Medicine·Sung Eun KimDeok-Won Lee
Apr 10, 2013·Acta Biomaterialia·Laura TreccaniKurosch Rezwan
Mar 30, 2013·Expert Opinion on Drug Delivery·Mohammad FazilJaved Ali
Aug 11, 2012·Bone·Elisa BoaniniAdriana Bigi
Feb 9, 2012·Advanced Drug Delivery Reviews·Maria-Pau GinebraEdgar B Montufar
Dec 1, 2011·Acta Biomaterialia·Susmita Bose, Solaiman Tarafder
Oct 22, 2011·Biomaterials·Elisa BoaniniAdriana Bigi
Aug 29, 2013·Journal of Biomedical Materials Research. Part a·M S HasanC A Scotchford
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Tianxing GongUrs O Häfeli
Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
Jun 13, 2014·Tissue Engineering. Part C, Methods·Anne BernhardtMichael Gelinsky
Apr 26, 2012·Chemical Reviews·Clémence QueffélecBruno Bujoli
Jul 12, 2012·Journal of Biomaterials Applications·Muhammad Sami HasanColin A Scotchford
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
Jan 19, 2018·Journal of Functional Biomaterials·Adriana Bigi, Elisa Boanini
Jul 10, 2013·Advanced Materials·Elisa BoaniniAdriana Bigi
Nov 19, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sergey V Dorozhkin
Oct 5, 2019·Connective Tissue Research·Kyoung-Je JangJong Hoon Chung