Functionalization of DNA-dendron supramolecular fibers and application in regulation of Escherichia coli association

ACS Applied Materials & Interfaces
Fen WuDongsheng Liu

Abstract

Specific carbohydrate recognition in biology is a dynamic process. Thus, supramolecular multivalent scaffolds with dynamic features have been applied to mimic this process. Herein, we prepared DNA-dendron supramolecular fibers and synthesized carbohydrate-oligonucleotide conjugates (C18-mannose). Via DNA hybridization, the C18-mannose could be guided onto the fiber platform and form multiple mannose-functionalized fibers, which can be utilized to agglutinate E. coli because of high affinity among multivalent mannose ligands and receptors on E. coli. In addition, via chain exchange reaction of DNAs, the E. coli could be dissociated by replacing multivalent mannose ligands with competitive unmodified DNA sequences. The association and dissociation processes of E. coli are confirmed by fluorescent microscope and transmission electron microscope (TEM). These results not only demonstrate the ability of DNA-dendron fibers in reversibly associating E. coli but also illustrate their potential to be an easily modified multivalent supramolecular platform.

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Citations

Dec 26, 2015·Chemical Reviews·Martina DelbiancoPeter H Seeberger
Feb 16, 2019·Advanced Materials·Yong Hu, Christof M Niemeyer
Aug 24, 2017·Chembiochem : a European Journal of Chemical Biology·Willem E M NotebornRoxanne E Kieltyka
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Aug 9, 2017·Journal of the American Chemical Society·Yuan GuoDejian Zhou

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