Functionalized β-cyclodextrin based potentiometric sensor for naproxen determination

Materials Science & Engineering. C, Materials for Biological Applications
Joanna Lenik, Renata Łyszczek

Abstract

Potentiometric sensors based on neutral β-cyclodextrins: (2-hydroxypropyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin and anionic β-cyclodextrin: (2-hydroxy-3-N,N,N-trimethylamino)propyl-β-cyclodextrin chloride for naproxen are described. Inclusion complexes of naproxen with the above-mentioned cyclodextrins were studied using IR spectroscopy. The electrode surface was made from PVC membranes doped with the appropriate β-cyclodextrin as ionophores and quaternary ammonium chlorides as positive charge additives that were dispersed in plasticizers. The optimum membrane contains heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin, o-nitrophenyloctyl ether and tetraoctyl ammonium chloride as a lipophilic salt. The electrode is characterized by a Nernstian response slope of -59.0 ± 0.5 mV decade(-1) over the linear range of 5.0 × 10(-5)-1.0 × 10(-2) mol L(-1) and the detection limit 1.0 × 10(-5) mol L(-1), as well as the response time 10s. It can be used in the pH range 6.2-8.5 for 10 months without any considerable deterioration. Incorporation of β-cyclodextrins improved the electrode selectivity towards naproxen ions from several inorganic and organic interferents and some com...Continue Reading

References

Dec 2, 2006·International Journal of Pharmaceutics·Thorsteinn Loftsson, Dominique Duchêne
Jan 16, 2007·Journal of Pharmaceutical Sciences·Emad L Izake
Apr 26, 2007·Angewandte Chemie·Eric Bakker, Ernö Pretsch
Aug 5, 2008·Current Drug Discovery Technologies·Patryk Bielecki, Wieslaw Wasiak
Jun 24, 2009·British Journal of Sports Medicine·J A PaoloniB Hamilton
Sep 5, 2013·Journal of AOAC International·Michael E El-KommosAhmed F Abdel Hakiem
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Joanna Lenik
Jan 1, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Joanna Lenik

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Citations

Oct 24, 2018·Food & Function·Michelle C LeeAlireza Abbaspourrad
Jul 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qian-Long WangLin-Sen Qing
Mar 4, 2017·Journal of Inclusion Phenomena and Macrocyclic Chemistry·Artur KasprzakMichal Bystrzejewski
Oct 14, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Yingge ShiYen Wei

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