Functionalized 129Xe contrast agents for magnetic resonance imaging.

Current Opinion in Chemical Biology
Olena Taratula, Ivan J Dmochowski

Abstract

The concept of 'xenon biosensor' for magnetic resonance imaging (MRI) was first proposed by a Berkeley team in 2001, with evidence that hyperpolarized 129Xe bound to a biotin-labeled cryptophane can detect streptavidin at much lower concentrations (nM-microM) than is typical for contrast-enhanced MRI experiments. 129Xe biosensors have undergone many recent developments to address challenges in molecular imaging. For example, cryptophanes that exhibit 10-fold higher xenon affinity with distinct 129Xe magnetic resonance spectra have been synthesized. Also relevant are dendrimeric cryptophane assemblies and inorganic zeolites that localize many 129Xe atoms to rare targets. Finally, this article considers biosensors that produce measurable changes in 129Xe chemical shift based upon the activity of oligonucleotides, proteins, or enzymes, and includes the first cell studies.

References

Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·A BifoneA Pines
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·B M GoodsonA Pines
Jun 27, 2000·NMR in Biomedicine·A K VenkateshM S Albert
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G DuhamelA Constantinesco
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M M SpenceP G Schultz
Jul 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Adam J MouléAlexander Pines
Mar 5, 2004·Chembiochem : a European Journal of Chemical Biology·J Manuel PerezRalph Weissleder
Nov 19, 2004·Journal of the American Chemical Society·Megan M SpenceAlexander Pines
Dec 13, 2005·Chembiochem : a European Journal of Chemical Biology·Thomas J LoweryDavid E Wemmer
Feb 2, 2006·NMR in Biomedicine·Willem J M MulderKlaas Nicolay
May 4, 2006·Journal of the American Chemical Society·Gaspard HuberPatrick Berthault
May 11, 2006·Journal of the American Chemical Society·Justin L MynarJean M J Fréchet
Oct 21, 2006·Science·Leif SchröderAlexander Pines
Dec 21, 2006·Journal of the American Chemical Society·E Janette RuizCynthia J Jameson
Jul 10, 2007·Journal of the American Chemical Society·P Aru HillIvan J Dmochowski
Aug 7, 2007·Journal of the American Chemical Society·Heather A FogartyJean-Pierre Dutasta
Aug 23, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Vincent RoyPatrick Berthault
Dec 13, 2007·Inorganic Chemistry·Lauren M Urbanczyk-PearsonThomas J Meade
May 8, 2008·Angewandte Chemie·Leif SchröderAlexander Pines
Oct 18, 2008·Bioconjugate Chemistry·Garry K SewardIvan J Dmochowski
Oct 25, 2008·Journal of Magnetic Resonance·Zackary I ClevelandThomas Meersmann
Dec 18, 2008·Chemical Reviews·Thierry Brotin, Jean-Pierre Dutasta
Jan 15, 2009·Journal of the American Chemical Society·Jennifer M ChambersIvan J Dmochowski
Feb 26, 2009·Journal of the American Chemical Society·P Aru HillIvan J Dmochowski
May 2, 2009·Angewandte Chemie·Andreas SchlundtChristian Freund

❮ Previous
Next ❯

Citations

Jun 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kamrun NaharFakhrul Ahsan
Mar 2, 2012·Inorganic Chemistry·Peter D FrischmannMark J MacLachlan
Mar 4, 2011·Journal of the American Chemical Society·Alexander R LippertChristopher J Chang
Feb 22, 2011·Organic Letters·Olena TaratulaIvan J Dmochowski
Jul 13, 2012·Organic Letters·Olena TaratulaIvan J Dmochowski
Jan 27, 2011·Nature Communications·Olena TaratulaIvan J Dmochowski
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·David R JacobsonIvan J Dmochowski
Apr 3, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Richard B Thompson, Warren H Finlay
Apr 16, 2016·Kona : Powder Science and Technology in Japan·Susanne R Youngren-OrtizMahavir B Chougule
Oct 4, 2012·NMR in Biomedicine·Christopher Witte, Leif Schröder
Oct 31, 2014·Contrast Media & Molecular Imaging·Dina V HingoraniMark D Pagel
Dec 17, 2014·Supramolecular Chemistry·Olena TaratulaIvan J Dmochowski
Oct 19, 2016·Accounts of Chemical Research·Yanfei Wang, Ivan J Dmochowski
Jan 6, 2015·Organic & Biomolecular Chemistry·B SenthilkumarC V Ramana
Jan 21, 2017·International Journal of Molecular Sciences·Ethel J Ngen, Dmitri Artemov
Feb 28, 2018·Nature Materials·George J LuMikhail G Shapiro
Dec 18, 2014·Chemical Communications : Chem Comm·Sergey KorchakLorenz Mitschang
Jun 21, 2014·Nature Chemistry·Mikhail G ShapiroVikram S Bajaj
Jun 2, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sergey KorchakLorenz Mitschang
Jul 6, 2014·Advanced Healthcare Materials·Matthias SchnurrLeif Schröder
Apr 5, 2013·Angewandte Chemie·Krishnan K PalaniappanMatthew B Francis
Aug 7, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Matthias SchnurrLeif Schröder
Nov 7, 2018·Chemical Communications : Chem Comm·Bin ZhangXin Zhou
Jun 18, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Francesco ZamberlanThomas Meersmann
Jan 26, 2013·Applied Magnetic Resonance·Sergey E KorchakLorenz Mitschang
Dec 1, 2015·Chemical Science·Lu GaoJeffery G Saven
Nov 8, 2014·Chemical Communications : Chem Comm·Akil I JosephK Travis Holman
May 28, 2019·Chirality·Orsola BaydounThierry Brotin
Jun 1, 2011·Chemical Science·Garry K SewardIvan J Dmochowski
Jan 3, 2018·Physical Chemistry Chemical Physics : PCCP·S KorchakL Mitschang
Sep 28, 2010·Physical Review Letters·A CommentG Bodenhausen
Mar 25, 2020·Inorganic Chemistry·Kang DuIvan J Dmochowski
Nov 15, 2018·The Journal of Organic Chemistry·Thierry BrotinJean-Christophe Mulatier
Apr 6, 2013·The Journal of Physical Chemistry. B·Natalia M SelivanovaYury G Galyametdinov
Nov 16, 2018·Bioconjugate Chemistry·Jabadurai Jayapaul, Leif Schröder
Jun 28, 2019·The Journal of Organic Chemistry·Orsola BaydounThierry Brotin
May 22, 2018·Analytical Chemistry·Serge D ZemerovIvan J Dmochowski
Jul 28, 2016·Bioconjugate Chemistry·Keunhong JeongMatthew B Francis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bioconjugate Chemistry
Garry K SewardIvan J Dmochowski
Journal of the American Chemical Society
Jennifer M ChambersIvan J Dmochowski
Chemical Communications : Chem Comm
Ténin TraoréBernard Rousseau
© 2022 Meta ULC. All rights reserved