Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration.

Scientific Reports
Eric Y ChenWei-Chun Chin

Abstract

Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal and digestive disorders. Applications of current mucolytics may yield short-term improvements but are continuously challenged by undesirable side-effects. While nanoparticles (NPs) can interact with mucin polymers,whether functionalized NPs can rectify mucus rheology is unknown. Herein, we report that carboxyl-functionalized NPs (24 nm and 120 nm) dramatically reduced mucin gel size and accelerated mucin matrix hydration rate (diffusivity). Our results suggest that carboxyl-functionalized NPs disperse mucin gels possibly by enhancing network hydration. This report highlights the prospective usages of carboxyl-functionalized NPs as a novel mucus dispersant or mucolytic agent in adjusting mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of patients suffering from relevant diseases.

References

Jan 1, 1990·Annual Review of Physiology·P Verdugo
Oct 1, 1986·The Biochemical Journal·J K SheehanI Carlstedt
Jan 1, 1984·The Biochemical Journal·J K Sheehan, I Carlstedt
Jan 1, 1995·Annual Review of Physiology·R BansilJ T LaMont
Dec 12, 1997·Journal of Microencapsulation·H S Kaş
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K R BhaskarJ T LaMont
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·W FengM King
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·J T BergerM C Rose
Apr 20, 1999·Pulmonary Pharmacology & Therapeutics·W FengM King
Oct 9, 1999·The European Respiratory Journal·E HoutmeyersM Decramer
Sep 30, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·E SudoM King
Jun 25, 2004·The New England Journal of Medicine·Peter J Barnes
Jul 1, 2005·Nursing·Bill Pruitt, Michael Jacobs
Jan 20, 2006·The New England Journal of Medicine·Scott H DonaldsonRichard C Boucher
Mar 11, 2006·American Journal of Respiratory Cell and Molecular Biology·Scott H RandellUNKNOWN University of North Carolina Virtual Lung Group
Nov 1, 1943·The Journal of Clinical Investigation·S FarberC L Maddock
Jun 27, 2006·Paediatric Respiratory Reviews·Bruce K Rubin
Sep 12, 2006·Peptides·Kerstin FelgentreffRobert Bals
Jan 16, 2007·Annual Review of Medicine·Richard C Boucher
Jan 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Samuel K LaiJustin Hanes
Jul 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Laura MayolMaria I La Rotonda
Sep 30, 2008·Biomacromolecules·Emanuela Di ColaThomas A Waigh
Jan 13, 2009·Advanced Drug Delivery Reviews·Richard A Cone
Aug 10, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eric Y T ChenWei-Chun Chin
Nov 19, 2010·PloS One·Eric Y T ChenWei-Chun Chin
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey

❮ Previous
Next ❯

Citations

Nov 13, 2016·Journal of Colloid and Interface Science·Vijayakumar N BoyaSubhash C Chauhan
Jan 3, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gustavo Ruiz-Pulido, Dora I Medina

❮ Previous
Next ❯

Methods Mentioned

BETA
rheology
dynamic laser scattering

Software Mentioned

GraphPad
NIS
Elements
Excel
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Eric Y ChenWei-Chun Chin
The Journal of Physical Chemistry. B
Yana ZnamenskayaVitaly Kocherbitov
Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
Evangelia Daviskas, Sandra D Anderson
© 2022 Meta ULC. All rights reserved