Functionalized graphene oxides for drug loading, release and delivery of poorly water soluble anticancer drug: A comparative study

Colloids and Surfaces. B, Biointerfaces
Neha KarkiNanda Gopal Sahoo

Abstract

In this work, the modification of graphene oxides (GOs) have been done with hydrophilic and biodegradable polymer, polyvinylpyrrolidone (PVP) and other excipient β -cyclodextrin (β-CD) through covalent functionalization for efficient loading and compatible release of sparingly water soluble aromatic anticancer drug SN-38 (7-ethyl-10-hydroxy camptothecin). The drug was loaded onto both GO-PVP and GO-β-CD through the π-π interactions.The release of drug from both the nanocarriers were analyzed in different pH medium of pH 7 (water, neutral medium), pH 5 (acidic buffer) and pH 12 (basic buffer). The loading capacity and the cell killing activity of SN-38 loaded on functionalized GO were investigated comprehensively in human breast cancer cells MCF-7.Our findings shown that the cytotoxicity of SN-38 loaded to the polymer modified GO was comparatively higher than free SN-38. In particular, SN-38 loaded GO-PVP nanocarrier has more cytotoxic effect than GO-β-CD nanocarrier against MCF-7 cells, indicating that SN-38 loaded GO-PVP nanocarrier can be used as promising material for drug delivery and biological applications.

Citations

Oct 1, 2019·Anti-cancer Agents in Medicinal Chemistry·Kikoleho RichaUpasana B Sinha
Feb 26, 2019·Biointerphases·Joshua D Morris, Christine K Payne
Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Sep 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Neha KarkiNanda Gopal Sahoo
Sep 21, 2019·Future Medicinal Chemistry·Giuseppe CirilloSilke Hampel
Jul 16, 2020·International Journal of Molecular Sciences·Mateusz KciukRenata Kontek
Sep 3, 2020·International Journal of Molecular Sciences·Horrick Sharma, Somrita Mondal
Feb 11, 2021·Journal of Drug Targeting·Mohaddeseh SajjadiSiavash Iravani
Jul 17, 2021·Journal of Nanobiotechnology·Guangman CuiGuangyu Yao
Dec 24, 2018·ACS Combinatorial Science·Geetmani Singh NongthombamRomesh Chandra Boruah

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