Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration

Scientific Reports
Xingdi ZhangYongsheng Li

Abstract

Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this difficulty has greatly hindered its development and use. To solve this problem, a simple powder processing technique has been successfully developed to fabricate a novel type of MBG scaffold (MBGS). Furthermore, amino or carboxylic groups could be successfully grafted onto MBGSs (denoted as N-MBGS and C-MBGS, respectively) through a post-grafting process. It was revealed that both MBGS and the functionalized MBGSs could significantly promote the proliferation and osteogenic differentiation of bMSCs. Due to its positively charged surface, N-MBGS presented the highest in vitro osteogenic capability of the three samples. Moreover, in vivo testing results demonstrated that N-MBGS could promote higher levels of bone regeneration compared with MBGS and C-MBGS. In addition to its surface characteristics, it is believed that the decreased degradation rate of N-MBGS plays a vital role in promoting bone regeneration. These findings indicate that M...Continue Reading

References

Jun 1, 1990·Journal of Biomedical Materials Research·T KokuboT Yamamuro
Nov 9, 2000·Biomaterials·D W Hutmacher
Mar 30, 2001·Advances in Dental Research·B Kasemo, J Gold
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Benjamin G KeselowskyAndrés J García
Dec 23, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Julian R Jones, Larry L Hench
Dec 27, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei Xia, Jiang Chang
Mar 1, 2006·Biomaterials·Xiaoxia YanDongyuan Zhao
Jun 22, 2006·Journal of the American Chemical Society·Francisco BalasMaría Vallet-Regí
Sep 7, 2007·Biochimica Et Biophysica Acta·R TzonevaT Groth
May 21, 2010·Journal of the Royal Society, Interface·Larry L Hench, Ian Thompson
Jul 28, 2010·Chemistry : a European Journal·Adolfo López-NoriegaMaría Vallet-Regí
Aug 26, 2010·Nanomedicine·Sandrine LavenusPierre Layrolle
Oct 20, 2011·Advanced Materials·María Vallet-Regí, Eduardo Ruiz-Hernández
Mar 28, 2012·Asian Pacific Journal of Tropical Medicine·Wei ZhangLei Peng

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Citations

Apr 19, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad ShoaibMuhammad Moazzam Naseer
Mar 31, 2017·Nanoscale·Yulin Li, Changsheng Liu
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Xiao WangXinquan Jiang
Nov 25, 2017·Advanced Healthcare Materials·Hwan D KimNathaniel S Hwang
Aug 31, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Deliang ZengXinquan Jiang
Oct 31, 2018·Biomaterials Science·Sara PourshahrestaniMark R Towler
Feb 23, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ahmad OryanHossein Baharvand
Apr 9, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S ChitraS Balakumar
Oct 8, 2016·Cellular and Molecular Life Sciences : CMLS·Parvin Abraham, Tessy Thomas Maliekal
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zoi TerzopoulouDimitrios Bikiaris
Aug 11, 2017·Journal of Tissue Engineering·Md Towhidul IslamKazi M Zakir Hossain
Nov 30, 2019·Biotechnology Letters·Xiaoyan WangLong Liu
May 12, 2020·Frontiers in Chemistry·Farzad ForoutanDaniela Carta
Dec 9, 2020·Journal of Biomedical Materials Research. Part a·Fabian WesthauserAldo R Boccaccini
Dec 30, 2020·Nanomaterials·Laura CasarrubiosMaría Teresa Portolés
Feb 23, 2021·Macromolecular Bioscience·Yi ZhuAnnie Shrestha
Mar 30, 2021·Bio-medical Materials and Engineering·Mario Pérez SayansPía López Jornet
Jan 19, 2021·ACS Biomaterials Science & Engineering·Michael T Frassica, Melissa A Grunlan
Jan 19, 2021·ACS Biomaterials Science & Engineering·Farzad ForoutanDaniela Carta

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Methods Mentioned

BETA
PCR
EISA
scanning electron microscopy
X-ray
atomic emission spectrometry
protein assay
dissection

Software Mentioned

SAS
Image
Pro Plus

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