Functionalized Surface Geometries Induce: "Bone: Formation by Autoinduction"

Frontiers in Physiology
Ugo Ripamonti

Abstract

The induction of tissue formation, and the allied disciplines of tissue engineering and regenerative medicine, have flooded the twenty-first century tissue biology scenario and morphed into high expectations of a fulfilling regenerative dream of molecularly generated tissues and organs in assembling human tissue factories. The grand conceptualization of deploying soluble molecular signals, first defined by Turing as forms generating substances, or morphogens, stemmed from classic last century studies that hypothesized the presence of morphogens in several mineralized and non-mineralized mammalian matrices. The realization of morphogens within mammalian matrices devised dissociative extractions and chromatographic procedures to isolate, purify, and finally reconstitute the cloned morphogens, found to be members of the transforming growth factor-β (TGF-β) supergene family, with insoluble signals or substrata to induce de novo tissue induction and morphogenesis. Can we however construct macroporous bioreactors per se capable of inducing bone formation even without the exogenous applications of the osteogenic soluble molecular signals of the TGF-β supergene family? This review describes original research on coral-derived calcium ph...Continue Reading

References

Nov 1, 1992·Matrix : Collagen and Related Research·U RipamontiA H Reddi
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I VlodavskyM Klagsbrun
Nov 12, 1965·Science·M R Urist
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Nov 1, 1993·Matrix : Collagen and Related Research·U RipamontiJ Van Wyk
Feb 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittB F Boyce
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U RipamontiJ Crooks
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·B A McBreartyE Heber-Katz
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Sarikaya
May 16, 2000·Biomaterials·H YuanX Zhang
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U RipamontiA H Reddi
Jan 31, 2002·Plastic and Reconstructive Surgery·Arun K GosainJohn L Ricci
Oct 31, 2003·Biomaterials·Shunsuke FujibayashiTakashi Nakamura
Jul 17, 2004·Journal of Cellular and Molecular Medicine·U Ripamonti
Dec 29, 2004·Biomaterials·Pamela HabibovicKlaas de Groot
Nov 1, 2005·International Journal of Oral and Maxillofacial Surgery·M HeliotisL di Silvio
Mar 25, 2006·Journal of Biomedical Materials Research. Part a·Pamela HabibovicKlaas de Groot
Apr 6, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Pamela HabibovicKlaas de Groot
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·Pamela Habibovic, Klaas de Groot
Dec 7, 2007·Biomaterials·Pamela HabibovicJake E Barralet
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Ugo RipamontiCarlo Ferretti
Dec 20, 2007·Plastic and Reconstructive Surgery·Ugo RipamontiMichael Edward Thomas
Apr 12, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Pamela HabibovicClemens A van Blitterswijk
Jan 30, 2009·Journal of Cellular and Molecular Medicine·Ugo Ripamonti
Jun 30, 2010·Expert Review of Medical Devices·Ugo Ripamonti, Laura Roden
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huipin YuanJoost D de Bruijn
Feb 26, 2011·Journal of Tissue Engineering·Laura E McNamaraMatthew J Dalby
May 5, 2011·World Journal of Biological Chemistry·Ugo Ripamonti

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Citations

Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingzheng LiHuipin Yuan
Aug 4, 2018·Frontiers in Physiology·Chafik Ghayor, Franz E Weber
Jul 17, 2018·BioMed Research International·Jian LiYubo Fan

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Methods Mentioned

BETA
scanning electron microscopy

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