Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus

Nanomaterials
Joomin LeeBong Joo Park

Abstract

In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,2'-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria (Staphylococcus aureus: S. aureus), including several strains of methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria (Escherichia coli). The functionalized ZnO@GA nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to...Continue Reading

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Citations

Aug 4, 2018·Bioinorganic Chemistry and Applications·Jinhuan JiangJiye Cai
Oct 19, 2019·IET Nanobiotechnology·Seyed Mohammad Amini, Abolfazl Akbari
Jul 30, 2020·Environmental Science and Pollution Research International·Asmaa N MohammedAmna A Kotp
Aug 8, 2021·Nanomaterials·Marta Fiedot-TobołaJoanna Cybińska
Feb 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Lina HuangPingyu Zhang

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Methods Mentioned

BETA
scanning electron microscopy
Transmission electron microscopy
X-ray
electron diffraction
fluorescence microscopy
PCA

Software Mentioned

Imaris

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