PMID: 2492452Feb 10, 1989Paper

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

Cell
A AshkenaziD J Capon

Abstract

The number of G proteins identified by molecular cloning exceeds the number of known G protein functions. Here we show that a cell can possess multiple G proteins that carry out a similar function, the activation of phospholipase C, but couple selectively to different receptors, which are endogenous to the cell or introduced by DNA transfection. These G proteins (termed Gp) can be distinguished by their sensitivity to pertussis toxin. The assignment of a given Gp pathway to specific receptors is confirmed by the additivity relationships of the PI hydrolysis response mediated by the different receptors. Significantly different amounts of PI hydrolysis are activated through each Gp pathway, suggesting that Gp proteins also differ in their coupling to phospholipase C. These results indicate that distinct Gp pathways in a given cell exist to couple different receptors to PI hydrolysis selectively, and may specify the nature of the cellular response to different receptors by determining the magnitude of PI hydrolysis.

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Citations

Mar 15, 1997·Microscopy Research and Technique·M M Magalhães, M C Magalhães
Mar 1, 1992·Neurochemical Research·G SorrentinoR Massarelli
Apr 1, 1995·Cellular and Molecular Neurobiology·J T LaitinenT Kokkola
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Mar 1, 1992·Neurochemistry International·L VallarJ Meldolesi
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Jan 1, 1992·Progress in Growth Factor Research·G Jones, G Carpenter
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R A ShapiroN M Nathanson
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C BizzarriD Corda
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J P Montmayeur, E Borrelli
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S S StojilkovićK J Catt
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderE C Kohn
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Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·E DippelG Schultz

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