DOI: 10.1101/498055Dec 17, 2018Paper

Functionally distinct high and low theta oscillations in the human hippocampus

BioRxiv : the Preprint Server for Biology
Abhinav GoyalJoshua Jacobs

Abstract

Based on rodent models, researchers have theorized that the hippocampus supports episodic memory and navigation via the theta oscillation, a ~4-10Hz rhythm that coordinates brain-wide neural activity. However, recordings from humans have indicated that hippocampal theta oscillations are lower in frequency and less prevalent than in rodents, suggesting interspecies differences in theta's function. To characterize human hippocampal theta, we examined the properties of theta oscillations throughout the anterior-posterior length of the hippocampus as neurosurgical subjects performed a virtual spatial navigation task. During virtual movement, we observed hippocampal oscillations at multiple frequencies from 2 to 14 Hz. The posterior hippocampus prominently displayed oscillations at ~8 Hz and the precise frequency of these oscillations correlated with the speed of movement, implicating these signals in spatial navigation. We also observed slower ~3-Hz oscillations, but these signals were more prevalent in the anterior hippocampus and their frequency did not vary with movement speed. Our results converge with recent findings to suggest an updated view of human hippocampal electrophysiology. Rather than one hippocampal theta oscillatio...Continue Reading

Related Concepts

Brain
Electrophysiology (Science)
Hippocampus (Brain)
Research Personnel
Rodent
Spatial Distribution
Theta Rhythm
Neurosurgical Procedures
Memory, Episodic
Brain Waves

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