Functionally diverse human T cells recognize non-microbial antigens presented by MR1

ELife
Marco LeporeGennaro De Libero

Abstract

MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages. In healthy individuals we identified MR1-restricted T cells (named MR1T cells) displaying diverse TCRs and reacting to MR1-expressing cells in the absence of microbial ligands. Analysis of MR1T cell clones revealed specificity for distinct cell-derived antigens and alternative transcriptional strategies for metabolic programming, cell cycle control and functional polarization following antigen stimulation. Phenotypic and functional characterization of MR1T cell clones showed multiple chemokine receptor expression profiles and secretion of diverse effector molecules, suggesting functional heterogeneity. Accordingly, MR1T cells exhibited distinct T helper-like capacities upon MR1-dependent recognition of target cells expressing physiological levels of surface MR1. These data extend the role of MR1 beyond microbial antigen presentation and indicate MR1T cells are a normal part of the human T cell repertoire.

References

Oct 18, 2002·Journal of Cellular Physiology·Gerald Thiel, Giuseppe Cibelli
Nov 5, 2002·Nature Immunology·Michael S VincentMichael B Brenner
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J MileyLonnie Lybarger
Jun 15, 2004·Journal of Virology·Michaela LucasPaul Klenerman
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Claire DevilderEmmanuel Scotet
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seddon Y ThomasAndrew D Luster
Oct 24, 2007·Current Opinion in Structural Biology·Dirk M Zajonc, Mitchell Kronenberg
Apr 30, 2008·The Journal of Experimental Medicine·Shouxiong HuangTed H Hansen
Aug 20, 2008·Nature Immunology·Shannon K BromleyAndrew D Luster
Mar 25, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hyun-Jin ShinChang-Woo Lee
May 30, 2009·Advances in Immunology·Nadia R CohenMichael B Brenner
Jun 10, 2010·Nature Reviews. Molecular Cell Biology·Mikko TaipaleSusan Lindquist
Jun 29, 2010·Nature Immunology·Lionel Le BourhisOlivier Lantz
Jul 9, 2010·PLoS Biology·Marielle C GoldDavid M Lewinsohn
Nov 3, 2010·Nature Immunology·Annemieke de JongD Branch Moody
Jan 20, 2011·European Journal of Immunology·Claudia de LallaGiulia Casorati
Mar 14, 2012·The Journal of Experimental Medicine·Rangsima ReantragoonJames McCluskey
Sep 8, 2012·Genome Research·Jennifer HarrowTim J Hubbard
Sep 25, 2012·Cell Metabolism·Wei Shao, Peter J Espenshade
Oct 12, 2012·Nature·Lars Kjer-NielsenJames McCluskey
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Jan 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jooeun BaeNikhil C Munshi
Mar 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin-Zi TangAntonio Bertoletti
Mar 16, 2013·Trends in Molecular Medicine·Thomas RauenGeorge C Tsokos
Jun 22, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Petra Bacher, Alexander Scheffold
Jul 13, 2013·Nature Communications·Onisha PatelJamie Rossjohn
Jul 23, 2013·Nature Immunology·Stefano VavassoriGennaro De Libero
Oct 17, 2013·PLoS Pathogens·Lionel Le BourhisOlivier Lantz
Apr 20, 2014·Frontiers in Immunology·Arjan Boltjes, Femke van Wijk
Jul 23, 2014·The Journal of Experimental Medicine·Marielle C GoldDavid M Lewinsohn
Jan 28, 2015·Cancer Immunology Research·Alfred ZippeliusPhilipp Müller

❮ Previous
Next ❯

Citations

Nov 28, 2017·Frontiers in Immunology·Xingxing Xiao, Jianping Cai
Feb 21, 2018·Immunology·Andrew ChancellorSalah Mansour
Feb 15, 2020·Cancers·Zuzanna LukasikKoen Venken
Nov 26, 2019·Current Protocols in Immunology·Michael N T SouterSidonia B G Eckle
Mar 19, 2020·Cancers·Elżbieta ChruścielNatalia Marek-Trzonkowska
Jan 28, 2020·Annual Review of Immunology·Nicholas M Provine, Paul Klenerman
Jan 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne WillingManuel A Friese
May 23, 2019·Nature Communications·Hui-Fern KoayDale I Godfrey
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Hamish E G McWilliamJose A Villadangos
Sep 24, 2020·Scientific Reports·Gitanjali A NarayananDavid M Lewinsohn
Aug 18, 2018·Frontiers in Immunology·François Trottein, Christophe Paget
Jan 22, 2020·Nature Immunology·Lucia Mori, Gennaro De Libero
Feb 23, 2020·Seminars in Immunopathology·Mathias SchmalerClaudia Daubenberger
Apr 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mariolina SalioVincenzo Cerundolo
Aug 7, 2020·Cancers·Pedro Flores-VillanuevaYong Li
Nov 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas A GherardinDale I Godfrey
Jun 23, 2020·Immunology and Cell Biology·Gitanjali A NarayananDavid M Lewinsohn
Sep 26, 2020·Frontiers in Immunology·Alexandra J CorbettZhenjun Chen
Mar 24, 2018·Immunology and Cell Biology·Hui-Fern KoayDaniel G Pellicci
Jan 20, 2018·Immunology and Cell Biology·James E UssherPaul Klenerman
Jan 25, 2018·Immunology and Cell Biology·Olivier Lantz, François Legoux
May 11, 2018·Mucosal Immunology·Mathias SchmalerGennaro De Libero
Jul 3, 2018·Frontiers in Immunology·Marco LeporeGennaro De Libero
May 16, 2020·Frontiers in Immunology·Alessandro VacchiniGennaro De Libero
Aug 14, 2019·Nature Immunology·Dale I GodfreyNicholas A Gherardin
Oct 6, 2020·Frontiers in Immunology·Marco P La MannaNadia Caccamo
Aug 21, 2020·The Journal of Biological Chemistry·Wael AwadJamie Rossjohn
Jun 26, 2020·Nature Reviews. Immunology·Daniel G PellicciStuart P Berzins
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Nov 14, 2020·Bioscience Reports·Zhiding WangLi Yu
Mar 17, 2021·Nature Communications·Sara De BiasiAndrea Cossarizza
Oct 15, 2020·Immunity·François LegouxOlivier Lantz
Mar 7, 2021·Cancer Immunology Research·Nicholas A GherardinRichard W Tothill
Jul 25, 2021·Cancers·Emilie BarsacChristophe Paget

❮ Previous
Next ❯

Datasets Mentioned

BETA
MF085360-MF085372
GSE81063

Methods Mentioned

BETA
FACS
flow cytometry
RNA-seq
PCR
ELISA
chip-seq

Software Mentioned

STAR aligner
Prism
GraphPad
EdgeR
NetworkX
Encode
Cytoscape
R
Milliplex analyst
GENCODE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.