Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering

Acta Biomaterialia
Heemin KangShyni Varghese

Abstract

Osteochondral tissue repair remains a significant challenge in orthopedic surgery. Tissue engineering of osteochondral tissue has transpired as a potential therapeutic solution as it can effectively regenerate bone, cartilage, and the bone-cartilage interface. While advancements in scaffold fabrication and stem cell engineering have made significant progress towards the engineering of composite tissues, such as osteochondral tissue, new approaches are required to improve the outcome of such strategies. Herein, we discuss the use of a single-unit trilayer scaffold with depth-varying pore architecture and mineral environment to engineer osteochondral tissues in vivo. The trilayer scaffold includes a biomineralized bottom layer mimicking the calcium phosphate (CaP)-rich bone microenvironment, a cryogel middle layer with anisotropic pore architecture, and a hydrogel top layer. The mineralized bottom layer was designed to support bone formation, while the macroporous middle layer and hydrogel top layer were designed to support cartilage tissue formation. The bottom layer was kept acellular and the top two layers were loaded with cells prior to implantation. When implanted in vivo, these trilayer scaffolds resulted in the formation o...Continue Reading

Citations

Mar 28, 2019·Tissue Engineering. Part B, Reviews·Yaima CamposLuis J Cruz
Dec 14, 2019·Advanced Materials·Yuze ZengShyni Varghese
Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haotian PanXiaodong Cao
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Aug 15, 2020·Biochemical Society Transactions·Mark LemoineFergal J O'Brien
Jun 15, 2019·Regenerative Biomaterials·Jiawei LiZhen Gu
Sep 5, 2020·Biomedical Engineering Online·Marjan Bahraminasab
Aug 11, 2020·Frontiers in Bioengineering and Biotechnology·Janeth Serrano-BelloMarco Antonio Alvarez-Perez
Nov 29, 2020·Journal of Materials Science. Materials in Medicine·Min ZhuZhongtang Liu
Nov 13, 2020·Tissue Engineering. Part B, Reviews·Wendy BalestriYvonne Reinwald
Jan 19, 2021·ACS Biomaterials Science & Engineering·Michael T Frassica, Melissa A Grunlan
Oct 28, 2021·Expert Reviews in Molecular Medicine·Martin Philipp DieterlePascal Tomakidi

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