Functionally improved bone in calbindin-D28k knockout mice.

Bone
David S MargolisYeong-Hau H Lien

Abstract

In vitro studies indicate that Calbindin-D28k, a calcium binding protein, is important in regulating the life span of osteoblasts as well as the mineralization of bone extracellular matrix. The recent creation of a Calbindin-D28k knockout mouse has provided the opportunity to study the physiological effects of the Calbindin-D28k protein on bone remodeling in vivo. In this experiment, histomorphometry, microCT, and bend testing were used to characterize bones in Calbindin-D28k KO (knockout) mice. The femora of Calbindin-D28k KO mice had significantly increased cortical bone volume (60.4% +/- 3.1) compared to wild-type (WT) mice (45.4% +/- 4.6). The increased bone volume was due to a decrease in marrow cavity area, and significantly decreased endosteal perimeters (3.397 mm +/- 0.278 in Calbindin-D28k KO mice, and 4.046 mm +/- 0.450 in WT mice). Similar changes were noted in the analysis of the tibias in both mice. The bone formation rates were similar in the femoral and tibial cortical bones of both mice. microCT analysis of the trabecular bone in the tibial plateau indicated that Calbindin-D28k KO mice had an increased bone volume (35.2% +/- 3.1) compared to WT mice (24.7% +/- 4.9) which was primarily due to increased trabecular...Continue Reading

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Citations

Jan 5, 2008·Calcified Tissue International·David S MargolisYeong-Hau H Lien
Nov 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fayez K Ghishan, Pawel R Kiela
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Feb 24, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Xuanyu LuXianghong Luan
Dec 23, 2008·Biochemical and Biophysical Research Communications·Sang-Hwan KoEui-Bae Jeung
Jan 22, 2015·Molecular and Cellular Biology·Omri BauerYoram Groner
Jan 30, 2018·Journal of Cellular Biochemistry·Li-Ping YangQun Zhao
Nov 6, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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