Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)

Human Molecular Genetics
Hongyan WangJerome F Strauss

Abstract

Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. We identified three single nucleotide polymorphisms (SNPs) at -799C/T, -381A/G and +17C/G from the major transcription start site in the MMP8 gene, and determined the functional significance of these SNPs by analyzing their impact upon MMP8 promoter activity and their association with preterm premature rupture of membranes (PPROM). The minor alleles +17 (G) and -381 (G) were in complete linkage disequilibrium. A promoter fragment containing the three minor alleles had 3-fold greater activity in chorion-like trophoblast cells (BeWo, JEG-3 and HTR-8/SVneo) compared with the major allele promoter construct. Electrophoretic mobility shift assays revealed differences in BeWo nuclear protein binding to oligonucleotides representing the -381 and -799 SNPs, suggesting that the minor alleles have reduced transcription factor binding. A case-control study of African-American neonates using allele-specific primers revealed a statistically significant association between the three minor allele haplotype, which displays the highest MMP8 promoter activity in ...Continue Reading

References

Aug 1, 1991·Biochemical Society Transactions·H NagaseG Salvesen
Oct 1, 1988·American Journal of Obstetrics and Gynecology·M R RajabiJ F Woessner
Jan 22, 1982·Nucleic Acids Research·S M Mount
Jan 1, 1995·Methods in Enzymology·H Tschesche
Jan 1, 1995·American Journal of Obstetrics and Gynecology·G D Bryant-Greenwood, S Y Yamamoto
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
May 3, 1996·The Journal of Biological Chemistry·A A ColeK E Kuettner
Mar 5, 1998·The New England Journal of Medicine·S Parry, J F Strauss
Mar 11, 1999·Obstetrical & Gynecological Survey·J D Hoffman, K Ward
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G MurphyJ Gavrilovic
May 2, 2000·The Journal of Biological Chemistry·J L Lauer-FieldsG B Fields
Jan 10, 2001·American Journal of Physical Anthropology·E J ParraM D Shriver
Nov 22, 2001·American Journal of Obstetrics and Gynecology·E MaymonS Edwin
Nov 22, 2001·American Journal of Obstetrics and Gynecology·S R AngusS Parry
May 8, 2002·Nature Reviews. Molecular Cell Biology·Constance E Brinckerhoff, Lynn M Matrisian
Mar 29, 2003·BioTechniques·Inna Tabansky, Dmitry I Nurminsky
Jun 26, 2003·Investigative Ophthalmology & Visual Science·De Quan LiStephen C Pflugfelder
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Fabián Arechavaleta-VelascoSamuel Parry

❮ Previous
Next ❯

Citations

May 22, 2013·Molecular Human Reproduction·G ChittoorR Duggirala
Sep 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·John P A Ioannidis, Fotini K Kavvoura
Jan 24, 2007·Physiological Reviews·Kendra J GreenleeFarrah Kheradmand
Jan 24, 2012·Reproductive Sciences·Jerome F Strauss
Dec 20, 2008·BMC Cancer·Patricia González-ArriagaAdonina Tardón
Sep 13, 2008·Pediatric Research·Emmanuel A AnumJerome F Strauss
Jul 7, 2011·World Journal of Gastrointestinal Oncology·Alexandra Mj LangersCornelis Fm Sier
Oct 31, 2013·Inflammation·Judith M RellaFlorian B Mayr
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kristen H TaylorJeremy F Taylor
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hongyan WangJerome F Strauss
Jul 19, 2014·Medical Oncology·Fabian Arechavaleta-VelascoLaura Diaz-Cueto
Jun 1, 2007·American Journal of Public Health·Richard David, James Collins
Dec 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschLami Yeo
Jan 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Mi LeeBo Hyun Yoon
Mar 16, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Panagiotis TsiartasBo Jacobsson
Sep 6, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroYeon Mee Kim
Dec 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Matthew J MingioneJames R Woods
Aug 26, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Konstantinos RavanosNikolaos Prapas
Dec 3, 2014·Pharmacology & Therapeutics·Shu Ye
May 24, 2011·Gynécologie, obstétrique & fertilité·C MéhatsM Breuiller-Fouché
Dec 25, 2009·Placenta·R MenonS J Fortunato
Dec 24, 2005·The Journal of Investigative Dermatology·Bettina HartensteinPeter Angel
May 11, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nicolas M OrsiNigel A B Simpson
Jan 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christina L AquilanteIssam Zineh
Nov 10, 2007·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Roger SmithHelena C Parkington
Sep 17, 2013·Molecular Genetics & Genomic Medicine·Derek L VanhilleJerome F Strauss
Mar 23, 2011·Journal of Cellular and Molecular Medicine·Julie DecockDylan R Edwards
Mar 19, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Edyta WieczorekEdyta Reszka
Mar 21, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Mehmet R Genc, Julianna Schantz-Dunn
Apr 24, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ramkumar Menon, Stephen J Fortunato
Sep 1, 2014·American Journal of Obstetrics and Gynecology·Jamie A BastekMichal A Elovitz
Feb 1, 2013·Mediators of Inflammation·Sébastien LengletFabrizio Montecucco
Aug 3, 2010·American Journal of Obstetrics and Gynecology·Roberto RomeroRamkumar Menon
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Zachary A-F KistkaLouis J Muglia
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Craig E PennellCaroline Relton

❮ Previous
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