Functions of CD8 T-cell subsets secreting different cytokine patterns

Seminars in Immunology
T R MosmannS Sad

Abstract

CD8+ T cells can differentiate into two effector phenotypes, Tc1 and Tc2, secreting different cytokine patterns. Both subsets are cytotoxic via the perforin and Fas pathways, and both kill resting and activated B cells, ruling out the possibility of cognate help, although Tc2 cells may provide bystander help. Both subsets induce inflammation with similar cellular infiltrates. Tc1 cytokine synthesis is limited by two mechanisms--IL-4 induces a permanent deficiency in cytokine secretion, and rapid killing of target cells limits CD8+ T-cell activation and cytokine production. These multiple CD8 T-cell activities provide a versatile set of immune functions.

Citations

Jan 6, 2006·Parasitology·D M McKay
Feb 25, 2000·Allergy·G Tau, P Rothman
Nov 30, 2005·The Proceedings of the Nutrition Society·Rebecca J Dearman, Ian Kimber
Nov 17, 1998·The Journal of Experimental Medicine·M J PennyB M Hall
Jun 8, 1999·The Journal of Experimental Medicine·H XieA H Lichtman
Mar 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y ZhangI N Mbawuike
Dec 19, 1998·Experimental Dermatology·K AsadullahW Sterry
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·J JasonW R Jarvis
Jun 6, 2008·Journal of Virology·Ross B FultonSteven M Varga
Jun 3, 2000·Annual Review of Immunology·K M MurphyT L Murphy
Mar 3, 2004·Biological & Pharmaceutical Bulletin·Mi-Sun KimHyung-Min Kim
Oct 24, 2013·Clinical & Developmental Immunology·Taisuke Ito
Apr 9, 2005·European Journal of Endocrinology·G AustE Schmücking
Sep 14, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·B ArnouxJ de Blic
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L F WangR H Lin
Jun 10, 2004·Pathology Oncology Research : POR·Anna CsiszárEva Pócsik
Jul 13, 2000·The New England Journal of Medicine·P J Delves, I M Roitt
Mar 26, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Samuel Paulo CibulskiPaulo Michel Roehe
Aug 30, 2008·Research in Veterinary Science·Shih-Yi PengPing-Chin Fan
Sep 11, 2007·Cellular Immunology·Tobias M NowackiMagdalena Tary-Lehmann
Oct 1, 2015·International Journal of Cardiology·Chandirasegaran MassilamanyJay Reddy
Apr 6, 2005·Clinical and Experimental Immunology·R C HoweG A Poland
Apr 27, 2004·Periodontology 2000·Kazuhisa Yamazaki, Takako Nakajima
Nov 18, 2003·The British Journal of Dermatology·T Schwarz
Mar 17, 2007·American Journal of Reproductive Immunology : AJRI·Tanya DimovaRayna Georgieva
Jan 13, 2009·Immunology·Pratip K ChattopadhyayMario Roederer
Mar 30, 2011·Journal of Reproductive Immunology·Michelle H NelsonGregg N Milligan
Jan 23, 2015·Expert Opinion on Therapeutic Targets·Yan LiangDong-Qing Ye
Oct 3, 2003·The Journal of Clinical Investigation·Nader NajafianSamia J Khoury
Sep 11, 2012·Journal of Photochemistry and Photobiology. B, Biology·Deyla Duarte Carneiro VilelaSílvia Regina de Almeida Reis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.