Nov 27, 2010

Functions of chondroitin sulfate and heparan sulfate in the developing brain

Neurochemical Research
Nobuaki MaedaKeisuke Kamimura

Abstract

Chondroitin sulfate and heparan sulfate proteoglycans are major components of the cell surface and extracellular matrix in the brain. Both chondroitin sulfate and heparan sulfate are unbranched highly sulfated polysaccharides composed of repeating disaccharide units of glucuronic acid and N-acetylgalactosamine, and glucuronic acid and N-acetylglucosamine, respectively. During their biosynthesis in the Golgi apparatus, these glycosaminoglycans are highly modified by sulfation and C5 epimerization of glucuronic acid, leading to diverse heterogeneity in structure. Their structures are strictly regulated in a cell type-specific manner during development partly by the expression control of various glycosaminoglycan-modifying enzymes. It has been considered that specific combinations of glycosaminoglycan-modifying enzymes generate specific functional microdomains in the glycosaminoglycan chains, which bind selectively with various growth factors, morphogens, axon guidance molecules and extracellular matrix proteins. Recent studies have begun to reveal that the molecular interactions mediated by such glycosaminoglycan microdomains play critical roles in the various signaling pathways essential for the development of the brain.

  • References63
  • Citations40

Citations

Mentioned in this Paper

Biochemical Pathway
Chondroitin Sulfate, Zinc Salt
Golgi Apparatus
Glycosaminoglycans
Enzymes, antithrombotic
Brain
Extracellular Matrix
Disaccharides
Acetylgalactosamine
Heparitin Sulfate

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Related Papers

The International Journal of Biochemistry & Cell Biology
Jessica C F KwokJames W Fawcett
Journal of Cellular and Molecular Medicine
Patrick du SouichEulàlia Montell
The Journal of Clinical Investigation
Jeffrey D Esko, U Lindahl
Chemical Biology & Drug Design
Neha S Gandhi, Ricardo L Mancera
© 2020 Meta ULC. All rights reserved