Functions of DNA damage machinery in the innate immune response to DNA virus infection

Current Opinion in Virology
Ben J Trigg, Brian J Ferguson

Abstract

DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cytokines. During DNA virus infection the detection of viral DNA genomes by pattern recognition receptors (PRRs) is essential for the initiation of IFNI responses and host defence against these pathogens. It is intriguing that a number of molecular mechanisms have been found to be common to both of these DNA-induced stress responses and this has potentially important consequences for both sides of the host/pathogen arms race.

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Nov 22, 2015·Current Opinion in Virology·Philip Stevenson
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kamila S GwiazdaAndrew M Scharenberg
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Aug 1, 2020·The Journal of General Virology·Dayana B HristovaBrian J Ferguson
Jun 21, 2018·Frontiers in Cellular and Infection Microbiology·Safder S Ganaie, Jianming Qiu
Jul 10, 2020·Cell·Mehdi BouhaddouNevan J Krogan
Aug 11, 2021·Viruses·Salla MattolaMaija Vihinen-Ranta

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