Functions of EpCAM in physiological processes and diseases (Review)

International Journal of Molecular Medicine
Li HuangJiao Guo

Abstract

EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which was originally identified as a tumor‑associated antigen due to its high expression level in rapidly growing epithelial tumors. Germ line mutations of the human EpCAM gene have been indicated as the cause of congenital tufting enteropathy. Previous studies based on cell models have revealed that EpCAM contributes to various biological processes including cell adhesion, signaling, migration and proliferation. Due to the previous lack of genetic animal models, the in vivo functions of EpCAM remain largely unknown. However, EpCAM genetic animal models have recently been generated, and are useful for understanding the functions of EpCAM. The authors here briefly review the functions and mechanisms of EpCAM in physiological processes and different diseases.

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Citations

Aug 23, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barun DasMamata Sivagnanam
Mar 19, 2019·Intractable & Rare Diseases Research·Saori Yamada-KanazawaHironobu Ihn
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May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danila CianciosiFrancesca Giampieri
Dec 27, 2019·Analytical Chemistry·Yingying JingHongda Wang

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Methods Mentioned

BETA
biopsies
biopsy
co-immunoprecipitation
electron microscopy
IECs
GTPase
nuclear translocation

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