Functions of myc:max in the control of cell proliferation and tumorigenesis

International Review of Cytology
P J Hurlin, Shala Dezfouli

Abstract

Deregulation and elevated expression of members of the Myc family of bHLHZip transcription factors are observed in a high percentage of tumors. This close association with human cancers has led to a tremendous effort to define their biological and biochemical activities. Although Myc family proteins have the capacity to elicit a wide range of cell behaviors, their principal function appears to be to drive cells into the cell cycle and to keep them there. However, forced expression of Myc profoundly sensitizes normal cells to apoptosis. Therefore, tumor formation caused by deregulated Myc expression requires cooperating events that disrupt pathways that mediate apoptosis. Myc-dependent tumor formation may also be impeded by a set of related bHLHZip proteins with the demonstrated potential to act as Myc antagonists in cell culture experiments. In this review, we examine the complex activities of Myc family proteins and how their actions might be regulated in the context of a network of bHLHZip proteins.

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Citations

Nov 20, 2009·Annual Review of Pharmacology and Toxicology·Verónica González, Laurence H Hurley
Apr 24, 2010·BMC Cancer·Kara C SedorisDonald M Miller
Nov 16, 2013·PloS One·Joseph LotemYoram Groner
Oct 17, 2008·Future Oncology·Ryan M YoungYosef Refaeli
Jul 17, 2012·Cell Transplantation·Takahiro HayashiToshifumi Ozaki
Jan 11, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jing-Chun HanJia Liu
Sep 29, 2009·Journal of Neurochemistry·D Allan Butterfield, Miranda L Bader Lange
Apr 14, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Mengquan LiLixin Guan
Sep 13, 2006·The FEBS Journal·Inken Wierstra, Jürgen Alves
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Mar 13, 2014·Human Genetics·Divya LenkalaR Stephanie Huang
Dec 21, 2005·Microbiology and Immunology·Tomoko HiranoSayaka Takase-Yoden
Jan 9, 2021·Cancer Cell·Ann BoijaRichard A Young

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