PMID: 26786872Jan 21, 2016Paper

Functions of Polo-Like Kinases: A Journey From Yeast To Humans

Protein and Peptide Letters
Rajni VaidAnuradha Sourirajan

Abstract

Polo-like kinases (PLKs) belong to the serine/threonine kinase subfamily, characterized by the presence of the signature motif called Polo-box domain. PLK members studied so far have emerged as the conserved regulator of cell cycle and cell division in eukaryotes. The Polo-box domain adds diversity to PLK functions by targeting the enzyme to an array of substrates found at different sub-cellular structures for exquisite regulation of cell cycle. More than a dozen members of PLK subfamily have been identified in the eukaryotic world except in the higher plants. Despite the similarities in governing cell division, PLKs have diverse and unique functions in different organisms. This review summarizes the plethora of functions of PLK in yeast to humans. Along with its classical functions, this review also emphasizes on the role of PLKs in regulating DNA replication, repair, genome integrity, development, and morphogenesis pathways. Perturbations in PLK functions have disease implications, such as cancer in humans, and thus human PLK1 is targeted for cancer therapeutics. PLKs also play a vital role in regulating several stages of meiotic cell division. Thus, PLKs are emerging as a unique class of proteins with multiple and diverse fu...Continue Reading

Citations

Mar 12, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Julia Alejandra PezukLuiz Gonzaga Tone
Dec 6, 2018·BMC Complementary and Alternative Medicine·Yoshihisa MatsushitaToru Furukawa
Feb 23, 2019·Viruses·Robert MeinekeHusni Elbahesh
Feb 23, 2021·EMBO Reports·Enrique AlfaroRocío Gómez

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