Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures

Electroencephalography and Clinical Neurophysiology
E W Lothman, G Somjen

Abstract

Paroxysmal activity in ventral roots induced by penicillin in decapitate cat spinal cords is associated with waves of depolarization of primary afferent fiber terminals. These paroxysmal depolarizations can be detected as spontaneously occurring negative dorsal root potentials (DRPs) and are associated with antidromic discharge of nerve impulses in dorsal root fibers; they can also be detected by testing the excitability of afferent nerve terminals by focal stimulation. Negative DRPs evoked by afferent nerve volleys are altered in waveform but not in amplitude during seizures induced by penicillin, although they are blocked by the administration of picrotoxin. While blocking afferent-evoked DRPs, picrotoxin does not interfere with paroxysmal DRP'S, INDICATING DIFFERENCES IN THE GENERATION OF THE Two phenomena, which nevertheless have some link in common, for the paroxysmal waves occlude the evoked DRP. Such occlusion would appear as blockade, if DRPs were recorded by condenser-coupled amplifiers. In the presence of pentobarbital penicillin suppresses evoked DRPs, but under such circumstances seizure activity is not observed. Extracellular potassium activity within spinal gray matter transiently increases during seizure activity...Continue Reading

References

Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Jan 1, 1975·Annual Review of Physiology·G G Somjen
Jan 1, 1969·Brain Research·G G Somjen
Dec 1, 1971·The Journal of Physiology·N Davidson, C A Southwick
Oct 27, 1972·Brain Research·R A Davidoff
Aug 1, 1974·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
Jan 1, 1973·Progress in Neurobiology·G G Somjen
Dec 1, 1972·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
Feb 1, 1974·Experimental Neurology·W J MoodyD A Prince
Feb 27, 1970·Science·D A Pollen, M C Trachtenberg
Mar 1, 1970·Experimental Neurology·A P Fertziger, J B Ranck
Jan 1, 1966·Experimental Brain Research·D R Curtis, R W Ryall
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS

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Citations

Jan 1, 1981·Neuroscience and Behavioral Physiology·V L EzrokhiI N Sharonova
Jan 1, 1992·Neir̆ofiziologiia = Neurophysiology·I V BatuevaR Veskov
Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Jul 1, 1979·Electroencephalography and Clinical Neurophysiology·P G KaufmannJ C Farmer
Sep 1, 1979·Electroencephalography and Clinical Neurophysiology·M J GutnickH D Lux
Oct 1, 1981·Electroencephalography and Clinical Neurophysiology·M Szente, F Pongrácz
Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Aug 2, 2002·European Journal of Pharmacology·Christian Steinhäuser, Gerald Seifert
Feb 22, 2001·Annual Review of Physiology·D A McCormick, D Contreras
Jul 11, 2000·The European Journal of Neuroscience·S HinterkeuserC Steinhäuser
Jul 1, 1977·Experimental Neurology·J DavenportW E Crill
Dec 9, 1977·Brain Research·J L Noebels, D A Prince
Sep 20, 2015·Progress in Neurobiology·Alexei VerkhratskyVedrana Montana
Jan 17, 2015·Neuroscience·C SteinhäuserG Carmignoto
Dec 1, 1986·Archives internationales de physiologie et de biochimie·V La GruttaV Savatteri

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