Functions of RNA N6-methyladenosine modification in cancer progression.

Molecular Biology Reports
Bing ChenFeng Xu

Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

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Citations

Jul 1, 2020·Frontiers in Oncology·Shanshan LuYiya Zhang
Jan 11, 2020·Frontiers in Oncology·Wenhui ZhengMing Gu
Aug 15, 2020·Cell Death & Disease·Hongmei LiuZhanjun Li
Dec 6, 2019·Molecular Cancer·Liuer HeGang Yin
Apr 9, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bi-Xin ZhengYuan-Xiang Tao
Dec 18, 2020·ACS Chemical Biology·Song MaoJia Sheng
Sep 3, 2021·Critical Reviews in Clinical Laboratory Sciences·Amandine AmalricChristophe Hirtz
Nov 19, 2021·Current Protocols·Johnsi MathivananJia Sheng

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Methods Mentioned

BETA
immunoprecipitation
immunoprecipitation sequencing
MeRIP-Seq

Software Mentioned

MeTCluster
R
Bioconductor
R package
MeTPeak
exomePeak

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