PMID: 8955906Jan 1, 1996Paper

Functions of the 5' leader of murine leukemia virus genomic RNA in virion structure, viral replication and pathogenesis, and MLV-derived vectors

Biochimie
A Corbin, J L Darlix

Abstract

Retroviruses are a family of widespread small animal viruses that can cause a variety of neoplastic and immunosuppressive diseases. Murine leukemia viruses (MuLV) have been used as model systems to investigate virion and genomic RNA structure, viral replication and variability, and pathogenesis. Detailed knowledge of the genetic structure of MuLV and of the viral life cycle has led to the development of MuLV-derived retroviral vectors for gene transfer with potential applications in human gene therapy. In this review we have summarized the properties and functions of the 5' domain, called the leader, of MuLV genomic RNA. The 5' leader is formed of small interspersed and superimposed genetic elements involved in every step of the viral life cycle. In addition, the 3' domain of the leader encodes the N-terminal part of glycosylated forms of the GAG polyprotein, also named Gross cell surface antigen (GCSA or glycoGAG) which is essential for full spreading and pathogenic abilities of the virus in the animal. Therefore, the 5' leader of MuLV genomic RNA appears to be a very attractive model to study structure-function relationships of a small and multifunctional genetic domain in vitro, in cell culture and in the animal.

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Citations

Jan 17, 2007·Nature Reviews. Microbiology·Laurent BalvayThéophile Ohlmann
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shyh-Ching LoHarvey J Alter
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M GaleM G Katze
Oct 13, 2011·Expert Review of Vaccines·Michael W Wolf, Udo Reichl
Feb 26, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kyle Summers, Bernard Crespi
Apr 22, 2011·Microscopy Research and Technique·Gustavo Ferreira MartinsPaulo Filemon Paolucci Pimenta

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