Functions of the adapter protein Cas: signal convergence and the determination of cellular responses

Oncogene
Amy H BoutonP J Bruce-Staskal

Abstract

Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function. Its predicted role as a scaffolding molecule based on its domain structure has been largely confirmed. Through its ability to undergo rapid changes in phosphorylation, subcellular localization and association with heterologous proteins, Cas may spatially and temporally regulate the function of its binding partners. Numerous proteins have been identified that bind to Cas in vitro and/or in vivo, but in only a few cases is there an understanding of how Cas may function in these protein complexes. To date, Cas-Crk and Cas-Src complexes have been most frequently implicated in Cas function, particularly in regards to processes involving regulation of the actin cytoskeleton and proliferation. These and other Cas protein complexes contribute to the critical role of Cas in cell adhesion, migration, proliferation and survival of normal cycling cells. However, under conditions in which these processes are deregulated, Cas appears to play a role in oncogenic transformation and perhaps metastasis. Therefore, in its capacity as an adapter protein,...Continue Reading

References

Jan 1, 1987·Annual Review of Cell Biology·R Jove, H Hanafusa
Sep 1, 1989·Molecular and Cellular Biology·A B ReynoldsJ T Parsons
Aug 1, 1972·Virology·I Kimura, L M Black
May 1, 1984·Cell and Tissue Kinetics·D J GrdinaR A White
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·T R Polte, S K Hanks
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·S TanakaK Nagashima
Aug 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A FoekensJ G Klijn
Jan 1, 1993·Fundamental & Clinical Pharmacology·G TavernierP Montastruc
Apr 5, 1996·Cell·Z ZhangE Ruoslahti
Apr 12, 1996·The Journal of Biological Chemistry·T NakamotoH Hirai
Jun 14, 1996·The Journal of Biological Chemistry·M MatsudaT Kurata
May 15, 1996·Biochemical and Biophysical Research Communications·K HamasakiY Nojima
May 1, 1996·Postgraduate Medical Journal·A J Stewart, D J Coltart
May 1, 1997·Biochemical Society Transactions·E RozengurtJ L Zugaza
Jul 1, 1997·Molecular and Cellular Biology·T NakamotoH Hirai

❮ Previous
Next ❯

Citations

Aug 9, 2011·Cellular and Molecular Life Sciences : CMLS·Yeping ZhouR Jeroen Pasterkamp
Mar 12, 2013·Cellular and Molecular Life Sciences : CMLS·Hidemasa GotoMasaki Inagaki
Jan 31, 2004·Cellular Signalling·Priscila M FonsecaSteven K Hanks
Mar 24, 2005·Journal of Molecular Biology·Magdalena WisniewskaRichard A Engh
Oct 16, 2009·Biochemistry·Shalini S YadavW Todd Miller
Dec 14, 2004·Nature Biotechnology·John RushMichael J Comb
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yingchun WangRichard L Klemke
Feb 4, 2010·The Journal of Biological Chemistry·Yongquan ShenGary S Goldberg
Sep 16, 2003·The Journal of Biological Chemistry·Gary S GoldbergW Todd Miller
Dec 6, 2003·Molecular Biology of the Cell·Paola Di StefanoPaola Defilippi
Jan 6, 2006·Molecular Biology of the Cell·Disha DadkeErica A Golemis
Aug 18, 2006·Molecular Biology of the Cell·Jing Shi, James E Casanova
Apr 2, 2004·Biology of Reproduction·Nikki P Y Lee, C Yan Cheng
Dec 12, 2012·Genes & Cancer·Harini KrishnanGary S Goldberg
Dec 12, 2012·Genes & Cancer·Masumi Tsuda, Shinya Tanaka
Sep 17, 2008·BMC Cell Biology·Alok Sharma, Bruce J Mayer
Oct 31, 2003·Cell Structure and Function·Kaori SatoSeiichi Kawashima
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan P Myers, Timothy M Gomez
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guofa LiuYi Rao
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Edward Htun van der HorstScott Powers
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·G M RiveraB J Mayer
Dec 11, 2013·Nucleic Acids Research·Chien-Hua PengWen-Ping Hsieh
May 5, 2009·Breast Cancer Research and Treatment·Arend BrinkmanLambert C J Dorssers
Oct 15, 2013·Oncogene·A B ReynoldsJ T Parsons
Jun 15, 2011·Nature Chemical Biology·Akash GulyaniKlaus M Hahn

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