Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory

Prion
José A del Río, Rosalina Gavín

Abstract

Since its discovery the cellular prion protein (encoded by the Prnp gene) has been associated with a large number of functions. The proposed functions rank from basic cellular processes such as cell cycle and survival to neural functions such as behavior and neuroprotection, following a pattern similar to that of Moore's law for electronics. In addition, particular interest is increasing in the participation of Prnp in neurodegeneration. However, in recent years a redefinition of these functions has begun, since examples of previously attributed functions were increasingly re-associated with other proteins. Most of these functions are linked to so-called "Prnp-flanking genes" that are close to the genomic locus of Prnp and which are present in the genome of some Prnp mouse models. In addition, their role in neuroprotection against convulsive insults has been confirmed in recent studies. Lastly, in recent years a large number of models indicating the participation of different domains of the protein in apoptosis have been uncovered. However, after more than 10 years of molecular dissection our view is that the simplest mechanistic model in PrP(C)-mediated cell death should be considered, as Ockham's razor theory suggested.

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Citations

Jun 13, 2012·Journal of Molecular Biology·Sepehr EhsaniGerold Schmitt-Ulms
Feb 24, 2017·Molecular Neurobiology·Laura UrreaJosé Antonio Del Río
Jan 9, 2018·Prion·Elena De Cecco, Giuseppe Legname
May 4, 2017·Molecular Neurobiology·Andreu Matamoros-AnglesJosé Antonio Del Río
Aug 2, 2017·Prion·Laura UrreaJosé Antonio Del Río
Apr 22, 2017·Frontiers in Molecular Biosciences·Andrew R Castle, Andrew C Gill
May 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Gerold Schmitt-UlmsSepehr Ehsani

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Methods Mentioned

BETA
a
transfection

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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