PMID: 7017192Dec 1, 1980

Fundamental and clinical studies of cefuroxime in pediatric purulent meningitis (author's transl)

The Japanese journal of antibiotics
Y ToyonagaM Hori


The following results were obtained from the fundamental and clinical studies of cefuroxime, a new synthetic cephalosporin, in pediatric patients with purulent meningitis. This drug was administered to 2 pediatric patients with purulent meningitis at the dose to 50 mg/kg, by intravenous drip infusion over 30 minutes and one shot intravenous injection respectively. When spinal fluid levels were determined, about 15 approximately 30% of the drug concentration in blood was found to transfer to spinal fluid at acute stage. Spinal fluid levels were about 4 approximately 7 micrograms/ml. When 4 pediatric patients with purulent meningitis were treated with the drug, the good results were obtained in all of them. The dose given was 200 approximately 300 mg/kg/day and the dosing duration was 14 approximately 22 days. No adverse reaction was noted, nor abnormal laboratory test values were noted.

Related Concepts

Cephalosporanic Acids
Drug Evaluation
Escherichia Coli Infections
Meningitis, Haemophilus Parainfluenzae
Cerebrospinal Fluid
Clinical Research

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