PMID: 7334577Nov 1, 1981Paper

Fundamental and clinical studies on tobramycin by intravenous drip infusion (author's transl)

The Japanese journal of antibiotics
Y ToyonagaM Hori

Abstract

Fundamental and clinical studies on tobramycin (TOB) by intravenous drip infusion were carried out, and following results were observed. 1) Serum concentration of TOB. TOB was administered 1.5 mg/kg or 3.0 mg/kg by intramuscular or intravenous drip infusion method to 16 pediatric patients. In 1.5 mg/kg dose, the mean peak serum concentration were 3.9 mcg/ml at the 1/4 approximately 1/2 hour after administration by intramuscular method, 4.9 mcg/ml at the 1/2 hour after administration by 30 minutes intravenous drip infusion, 6.4 mcg/ml at 1 hour by 60 minutes intravenous drip infusion method. The half lives (T 1/2) of TOB in those methods, were 1.48, 1.42, 1.26 hours, respectively. In 3.0 mg/kg dose schedule by 30 or 60 minutes intravenous drip infusion method, the mean peak serum concentrations were 11.5 mcg/ml, 8.0 mcg/ml at the end of infusion, respectively. Those of the T 1/2 were 1.54, 1.24 hours. Pharmacokinetic parameters of TOB were following results. The ranges of Vd (apparent volume of distribution), K10 (elimination constant (hr-1)), T 1/2 were 0.20 approximately 0.34 L, 0.63 approximately 1.37 hr-1, 1.20 approximately 2.07 hrs., respectively and there was no significant difference in the serum concentrations and in th...Continue Reading

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