Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Stefanie KuertenDoychin N Angelov

Abstract

Multiple sclerosis (MS) is characterized by a dynamic inflammatory process in which CNS lesions of distinct cellular composition coexist. In particular the formation of B cell plaques has been ascribed an important role as predictor of disease progression. Here we show that the novel MBP-PLP fusion protein (MP4)-induced experimental autoimmune encephalomyelitis (EAE) of C57BL/6 mice fulfils these criteria inducing differential cellular infiltration of B cells, T cells, macrophages and granulocytes and permitting the quantification and staging of the disease. On the contrary, both key features - dynamic CNS inflammation and B cell infiltration - were absent in the classical MOG:35-55-induced EAE of C57BL/6 mice, which was characterized by a static CD4(+) T cell and macrophage-mediated CNS immunopathology throughout the disease. MP4-induced EAE may thus provide a unique opportunity for studying immune-pathomechanisms of the disease that have been previously neglected due to experimental shortcomings in murine EAE.

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Citations

Oct 16, 2013·Journal of Neuroinflammation·Ganta Vijay ChaitanyaJonathan S Alexander
May 12, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mascha S RecksStefanie Kuerten
Mar 23, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Helena BatoulisStefanie Kuerten
Jul 1, 2012·Multiple Sclerosis and Related Disorders·Natalia Pikor, Jennifer L Gommerman
Aug 28, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sita JaveriStefanie Kuerten
Aug 10, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Helena BatoulisStefanie Kuerten
Jun 1, 2010·Rheumatic Diseases Clinics of North America·Angelica GierutRichard M Pope
Feb 23, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tim NiehuesCatharina Schuetz
Jul 2, 2009·Annals of the New York Academy of Sciences·Nadia Danilova, Chris T Amemiya
Nov 17, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Helena BatoulisStefanie Kuerten
Nov 26, 2010·Annals of the New York Academy of Sciences·Alexandre AlcaïsJean-Laurent Casanova
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Jan 19, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Stefanie KuertenKlaus Addicks
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Jan 18, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Marjan GharagozlooMarianna Foldvari
Aug 1, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mascha S RecksStefanie Kuerten
Oct 3, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ning-Ning LiXiao-Ting Wu
Jul 12, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hon-Chi LeeWin-Kuang Shen
Jun 7, 2011·Biophysical Journal·Philippe RobertLaurent Limozin
Jul 21, 2016·Scientific Reports·Damiano M RovitusoStefanie Kuerten
Oct 14, 2016·JCI Insight·Kerstin RennerMatthias Mack
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May 17, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Stefanie KuertenKlaus Addicks
Sep 24, 2020·International Journal of Molecular Sciences·Thomas BreakellStefanie Kuerten
Nov 24, 2020·Frontiers in Neurology·Rittika ChunderStefanie Kuerten
Feb 27, 2021·Multiple Sclerosis and Related Disorders·Berenice Anabel SilvaCarina Cintia Ferrari
Apr 4, 2021·International Journal of Molecular Sciences·Christopher KapitzaJürgen Wörl
Jun 26, 2021·Frontiers in Immunology·Krista D DiSanoAndrew R Pachner

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