PMID: 11934228Apr 6, 2002Paper

Fundamental effects of particle morphology on lung delivery: predictions of Stokes' law and the particular relevance to dry powder inhaler formulation and development

Pharmaceutical Research
Timothy M CrowderT B Martonen

Abstract

Key factors that contribute to the aerodynamic properties of aerosol particles are found in Stokes' law. These factors may be monitored or controlled to optimize drug delivery to the lungs. Predictions of the aerodynamic behavior of therapeutic aerosols can be derived in terms of the physical implications of particle slip, shape and density. The manner in which each of these properties have been used or studied by pharmaceutical scientists to improve lung delivery of drugs is readily understood in the context of aerosol physics. Additional improvement upon current aerosol delivery of particulates may be predicted by further theoretical scrutiny.

Citations

May 29, 2014·Pharmaceutical Research·Jennifer WongHak-Kim Chan
Aug 25, 2018·Pharmaceutical Research·Erin M WilsonJoseph M DeSimone
Sep 20, 2019·Cancers·Adi Karsch-BlumanOfra Benny
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hirokazu Okamoto, Kazumi Danjo
Jun 23, 2007·Angewandte Chemie·Andreas Greiner, Joachim H Wendorff
Aug 21, 2008·Expert Opinion on Drug Delivery·Hak-Kim Chan
Jan 15, 2010·Inhalation Toxicology·Camby Mei King SeJiyuan Tu
Jun 26, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Matteo GoldoniAntonio Mutti
Oct 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Caleb F AndersonHonggang Cui
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lucila Garcia-ContrerasDavid Edwards
Dec 28, 2006·Pharmaceutical Research·Boris Y ShekunovAlbert H L Chow
Sep 19, 2012·Drug Delivery·Wipaporn RojanaratTeerapol Srichana
Sep 14, 2012·Journal of Environmental Monitoring : JEM·Susana Addo NtimSomenath Mitra
Dec 24, 2014·Expert Opinion on Drug Delivery·Mohamed Ehab AliAlf Lamprecht
Feb 2, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Chantal DarquenneOtmar Schmid
Dec 9, 2017·Therapeutic Delivery·Gabriela Daisy HadiwinotoRichard Lakerveld
Jul 22, 2020·Inhalation Toxicology·Matthew D WrightRachel Smith
Dec 21, 2006·Environmental Monitoring and Assessment·P VanderstraetenZ Y Offer
Dec 25, 2010·Nanomedicine·Fernanda AndradeBruno Sarmento
Dec 12, 2012·Pharmaceutical Research·Alan B WattsRobert O Williams
Jan 25, 2007·Pharmaceutical Research·Albert H L ChowBoris Y Shekunov
Aug 6, 2020·Pharmaceutics·Bishal Raj AdhikariShyamal C Das
May 13, 2010·Expert Opinion on Drug Delivery·Leslie Y YeoDavid A V Morton
Jul 15, 2020·Advanced Drug Delivery Reviews·Anthony J Hickey
Feb 18, 2021·Pharmaceutical Development and Technology·Tamara AthamnehClaudia S Leopold
Sep 25, 2017·Advanced Drug Delivery Reviews·Weiwei GaoLiangfang Zhang
Jan 8, 2021·International Journal of Pharmaceutics: X·Jonas RudénGöran Alderborn
Apr 5, 2021·International Journal of Pharmaceutics·Shadi YaqoubiHamed Hamishehkar
Nov 15, 2011·International Journal of Pharmaceutics·C TsagogiorgasM Quintel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Respiratory Care
S Suarez, Anthony J Hickey
International Journal of Pharmaceutics
Martyn F BiddiscombePeter J Barnes
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Nashwa El-GendyCory Berkland
© 2022 Meta ULC. All rights reserved