Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusion

Trends in Endocrinology and Metabolism : TEM
Ola Nilsson, Jeffrey Baron

Abstract

Longitudinal bone growth occurs rapidly in early life but then slows and, eventually, ceases. The decline in growth rate is caused primarily by a decrease in the rate of chondrocyte proliferation and is accompanied by structural changes in growth plate cartilage. This programmed senescence does not appear to be caused by hormonal or other systemic mechanisms but is intrinsic to the growth plate itself. In particular, recent evidence indicates that senescence might occur because stem-like cells in the resting zone have a finite proliferative capacity, which is exhausted gradually. In some mammals, including humans, proliferative exhaustion is followed by epiphyseal fusion, an abrupt event in which the growth plate cartilage is replaced completely by bone.

References

Jul 1, 1985·The Journal of Pediatrics·O H PescovitzG B Cutler
Sep 1, 1972·Cell and Tissue Kinetics·K V Walker, N F Kember
Mar 1, 1968·American Journal of Diseases of Children·T J Sigurjonsdottir, A B Hayles
Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Jun 3, 1983·Science·V L Wilson, P A Jones
Aug 15, 1994·Microscopy Research and Technique·E B Hunziker
Oct 20, 1994·The New England Journal of Medicine·E P SmithK S Korach
Dec 1, 1995·The Journal of Clinical Endocrinology and Metabolism·A MorishimaK Qin
Jul 1, 1996·Genes & Development·D CobrinikT Jacks
Jul 10, 1997·The New England Journal of Medicine·C CaraniE R Simpson
Aug 27, 1998·The New England Journal of Medicine·J P BilezikianM M Grumbach
May 27, 1999·Journal of Pediatric Orthopedics·D G StevensC V Bowen
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J WangC A Bondy
Dec 10, 1999·Experimental Cell Research·W Wei, J M Sedivy
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Durand, M Raff
Jan 3, 2001·Developmental Biology·F LupuA Efstratiadis
Feb 24, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·M M Grumbach
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J O CheungM E Grant
Mar 22, 2001·The Journal of Biological Chemistry·J I Young, J R Smith
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WeiseJ Baron
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·R H Gomer
Jan 15, 2002·Advances in Experimental Medicine and Biology·D L Hadsell, G Abdel-Fattah
May 16, 2003·Nature·Henry M Kronenberg
Jul 31, 2003·Cell·Kenkichi MasutomiWilliam C Hahn
May 1, 1958·The Anatomical Record·M L MOSS, C R NOBACK
Aug 31, 1963·Nature·J M TANNER
Dec 13, 2003·Endocrine Reviews·B C J van der EerdenJ M Wit
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Martina WeiseJeffrey Baron
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kazuto HoshiHiroshi Kawaguchi

❮ Previous
Next ❯

Citations

Jun 7, 2008·Pediatric Research·Maria ChangJeffrey Baron
Nov 28, 2008·Endocrinology·Gabriela P FinkielstainJeffrey Baron
Apr 18, 2009·Journal of Applied Physiology·Maria A SerratCornelia E Farnum
Sep 15, 2010·PLoS Biology·Lewis Wolpert
Jun 1, 2014·Revista brasileira de reumatologia·Tâmara Kelly Delgado Paes BarretoSílvia Regina Arruda de Moraes
Dec 16, 2006·Bone·Jacob E LazarusJeffrey Baron
Oct 25, 2016·Clinical Medicine Insights. Endocrinology and Diabetes·Jesús DevesaPablo Devesa
Jul 4, 2009·Journal of Tissue Engineering and Regenerative Medicine·Christoph BrochhausenC James Kirkpatrick
Nov 11, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anenisia C AndradeOla Nilsson
Oct 21, 2015·Endocrine Reviews·Alberto Roselló-Díez, Alexandra L Joyner
Oct 18, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·G Gat-YablonskiM Phillip
Nov 21, 2013·Journal of Evolutionary Biology·M GeigerM R Sánchez-Villagra
Sep 16, 2016·The American Journal of Clinical Nutrition·Hoi Lun ChengKatharine Steinbeck
Jun 28, 2012·The Journal of Clinical Endocrinology and Metabolism·Annemieke J LemAnita C S Hokken-Koelega
Dec 22, 2017·Evolutionary Anthropology·Conrad Stephen Brimacombe
Jun 20, 2018·Frontiers in Endocrinology·Holly L RacineMaria A Serrat
Mar 28, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Helen KaliraiJan-M Wit
Jan 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Mark C LeeQian Chen
Nov 5, 2017·Nature Communications·Changjun LiMei Wan
Jun 23, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Isabelle M Vea, Alexander W Shingleton
Apr 25, 2019·Animal Models and Experimental Medicine·Adamu Abdul AbubakarLoqman Mohamad Yusof
Jul 26, 2017·ELife·Alberto Roselló-DíezAlexandra L Joyner
Dec 7, 2007·The Journal of Experimental Biology·Christine M Dengler-Crish, Kenneth C Catania
Oct 27, 2015·Biology Open·Kyriel M PineaultDeneen M Wellik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Endocrine Development
Julian C LuiJeffrey Baron
Proceedings of the National Academy of Sciences of the United States of America
M WeiseJeffrey Baron
Endocrine Development
Julian C Lui, Jeffrey Baron
Hormone Research
Ola NilssonJeffrey Baron
© 2021 Meta ULC. All rights reserved