Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias.

International Journal of Molecular Sciences
Hiroshi MitomaMario Manto

Abstract

In the last years, different kinds of limbic encephalitis associated with autoantibodies against ion channels and synaptic receptors have been described. Many studies have demonstrated that such autoantibodies induce channel or receptor dysfunction. The same mechanism is discussed in immune-mediated cerebellar ataxias (IMCAs), but the pathogenesis has been less investigated. The aim of the present review is to evaluate what kind of cerebellar ion channels, their related proteins, and the synaptic machinery proteins that are preferably impaired by autoantibodies so as to develop cerebellar ataxias (CAs). The cerebellum predictively coordinates motor and cognitive functions through a continuous update of an internal model. These controls are relayed by cerebellum-specific functions such as precise neuronal discharges with potassium channels, synaptic plasticity through calcium signaling pathways coupled with voltage-gated calcium channels (VGCC) and metabotropic glutamate receptors 1 (mGluR1), a synaptic organization with glutamate receptor delta (GluRδ), and output signal formation through chained GABAergic neurons. Consistently, the association of CAs with anti-potassium channel-related proteins, anti-VGCC, anti-mGluR1, and Glu...Continue Reading

References

Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Hirano, H Ohmori
Aug 8, 1988·The Journal of Comparative Neurology·R M Napper, R J Harvey
Jan 1, 1966·Experimental Brain Research·J C EcclesK Sasaki
Nov 14, 1997·Neuroscience Research·R Vigot, C Batini
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·A PintoJ Boot
Jan 6, 2000·The New England Journal of Medicine·P Sillevis SmittR Shigemoto
Apr 28, 2000·Journal of the Neurological Sciences·H MitomaH Mizusawa
Dec 2, 2000·Nature Neuroscience·S S WangM Häusser
Jan 5, 2002·The New England Journal of Medicine·M C DalakasB McElroy
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Nov 5, 2002·Nature Reviews. Neuroscience·Masao Ito
Feb 26, 2003·Annals of Neurology·Michiel CoesmansChris I de Zeeuw
Mar 18, 2003·Journal of the Neurological Sciences·Hiroshi MitomaHidehiro Mizusawa
May 24, 2003·Brain : a Journal of Neurology·Setareh Shams'iliPeter Sillevis Smitt
Jul 2, 2003·Nature Neuroscience·Hirokazu HiraiMichisuke Yuzaki
Oct 15, 2003·Neuron·David S Bredt, Roger A Nicoll
Jun 24, 2004·Journal of Neurophysiology·Fatemeh S AfshariIndira M Raman
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruce E McKayRay W Turner
Nov 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wataru Kakegawa, Michisuke Yuzaki
Jan 26, 2006·Brain : a Journal of Neurology·Jeremy D Schmahmann, David Caplan
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tetsuya TatsukawaKazuhiko Yamaguchi
Sep 30, 2006·Brain & Development·Tomoyuki ShimokazeKiyoshi Hayasaka
Nov 23, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Kazuyuki IshidaHidehiro Mizusawa
Jun 30, 2007·Annals of Neurology·Mario-Ubaldo MantoJérome Honnorat
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edward ZaghaBernardo Rudy
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yaping Joyce LiaoRichard W Tsien
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kogo TakamiyaDavid J Linden
Jun 7, 2008·Journal of the Neurological Sciences·Kazuyuki IshidaHidehiro Mizusawa

❮ Previous
Next ❯

Citations

Mar 24, 2021·The Cerebellum·Hiroshi MitomaMario Manto

❮ Previous
Next ❯

Software Mentioned

PERM

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.