Fundamental role of heme oxygenase in the protection against ischemic acute renal failure

Japanese Journal of Pharmacology
Reiko AkagiShigeru Sassa

Abstract

Oxidative stress conditions such as oxidant stimuli, inflammation, exposure to xenobiotics and ionizing irradiation provoke cellular responses, principally involving transcriptional activation of genes encoding proteins that participate in the defense against oxidative tissue injuries. Excess of free heme, which is released from hemeproteins under these conditions, may constitute a major threat because it catalyzes the formation of reactive oxygen species. Exposure of mammalian cells to oxidative stimuli induces heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, as well as the 32-kDa heat shock protein. In various tissue injury systems, HO-1 induction has been shown to confer protection, while its abrogation has been shown to accelerate cellular injuries. In this review, recent findings concerning the role of HO-1 as a protective response against oxidative stress conditions are summarized, with a particular emphasis on its protective role in ischemic acute renal failure.

References

Aug 1, 1979·Kidney International·W F Finn, R L Chevalier
Jul 1, 1992·The Journal of Clinical Investigation·K A NathM E Rosenberg
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Jan 1, 1987·Annals of the New York Academy of Sciences·G S Drummond
Nov 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Ries, J Klastersky
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Jul 15, 1997·European Journal of Biochemistry·W K McCoubreyM D Maines
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Jan 12, 1999·The Journal of Clinical Investigation·A YachieS Koizumi
Feb 7, 2001·Critical Care Medicine·H ShimizuR Akagi
May 12, 2000·American Journal of Physiology. Renal Physiology·F ShiraishiA Agarwal
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·L ColeJ H Reeves
Oct 4, 2000·The Journal of Experimental Medicine·S BrouardM P Soares
Jun 30, 2001·Intensive Care Medicine·S G Holt, K P Moore
Jul 20, 2002·Critical Care Medicine·Narushi TodaReiko Akagi

❮ Previous
Next ❯

Citations

Jul 10, 2010·Experimental & Translational Stroke Medicine·Muzamil AhmadSylvain Doré
Mar 14, 2009·The Tohoku Journal of Experimental Medicine·Akio IidaKazuhiko Igarashi
Mar 24, 2004·Free Radical Biology & Medicine·Pengfei GongNatalia Nieto
Apr 23, 2013·Experimental Hematology·Xiaobai PatrinostroTroy C Lund
Jan 25, 2005·Nephrology·Christine PercyGlenda Gobé
Sep 24, 2004·European Journal of Clinical Investigation·K KloucheJ P Cristol
Sep 9, 2006·Journal of Gastroenterology and Hepatology·Arthur I Cederbaum
Aug 28, 2012·The Journal of Surgical Research·Stephan BortscherMarcus Overhaus
Dec 5, 2014·Environmental Monitoring and Assessment·Ekambaram Padmini, Jayachandran Tharani
Jan 6, 2017·Stem Cells and Development·Shahensha ShaikRam Devireddy
Nov 16, 2004·Archives of Biochemistry and Biophysics·Pengfei GongArthur I Cederbaum
Jul 24, 2004·Anesthesia and Analgesia·Masao HayashiKiyoshi Morita
Sep 4, 2004·Antioxidants & Redox Signaling·Toru TakahashiShigeru Sassa
Jul 22, 2005·Journal of the American Society of Nephrology : JASN·Sreenivas LaxmananSoumitro Pal
Sep 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Miguel G SalomFrancisco J Fenoy
Jun 5, 2003·The Journal of Biological Chemistry·Pengfei GongNatalia Nieto
Apr 4, 2013·American Journal of Nephrology·Aleksandra KezicMilica Bajcetic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.