Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan

PloS One
Tsutomu YasukawaFumi Gomi

Abstract

Abnormal fundus autofluorescence (FAF) potentially precedes onset of late age-related macular degeneration (AMD) in Caucasian patients. Many differences exist between Asian and Caucasian patients regarding AMD types and severity, gender, and genetic backgrounds. We investigated the characteristics of abnormal FAF and retinal sensitivity in the fellow eyes of Japanese patients with unilateral neovascular AMD. Sixty-six patients with unilateral neovascular AMD and abnormal FAF in the fellow eye were enrolled in this multicenter, prospective, observational study. The best-corrected visual acuity, fundus photographs, FAF images, and retinal sensitivity on microperimetry were measured periodically for 12 months. The FAF images were classified into eight patterns based on the International Fundus Autofluorescence Classification Group. The points measured by microperimetry were superimposed onto the FAF images and fundus photographs and classified as "within," "close," and "distant," based on the distance from the abnormal FAF and other findings. The relationship between the location of the baseline abnormal FAF and retinal sensitivity was investigated. In Japanese patients, patchy (33.3%) and focally increased (30.3%) patterns predom...Continue Reading

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Citations

Mar 27, 2021·Journal of Medicinal Food·Beatriz da Silva Rosa BonadimanMargarete Dulce Bagatini

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Methods Mentioned

BETA
RAP

Software Mentioned

R
MP
SAS
nlme
Nidek Advanced Vision Information System

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