PMID: 20099229Jan 26, 2010Paper

Fundus autofluorescence and spectral domain optical coherence tomography in early detection of Plaquenil maculopathy

European Journal of Ophthalmology
Amy T KelmensonKakarla V Chalam

Abstract

To report fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) findings in a patient with early hydroxychloroquine maculopathy. A 50-year-old man presented with complaints of ring-like shadows in front of his eyes. He had been on hydroxychloroquine (Plaquenil) 400 mg orally twice daily for 10 years (5.14 mg/kg/day). Fundus examination revealed granular hypopigmentation in an arcuate pattern in the inferior parafoveal area bilaterally. The patient underwent further evaluation with SD-OCT and FAF imaging. Functional changes were assessed by microperimetry. Hypopigmented lesions on the fundus were autofluorescent and SD-OCT corresponding to this area revealed loss of inner segment-outer segment, suggesting loss of photoreceptor layer in the affected area with underling dysfunctional retinal pigment epithelium. Findings on SD-OCT and FAF imaging support the histopathologic findings described in cases of hydroxychloroquine maculopathy.

References

Jun 15, 2007·Archives of Ophthalmology·Julio A Rodriguez-PadillaJames G Fujimoto
Mar 11, 2008·Retina·Steffen Schmitz-ValckenbergRichard F Spaide

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Citations

Nov 5, 2011·Cutaneous and Ocular Toxicology·Won June LeeByung Ro Lee
Jan 3, 2012·Journal of Ophthalmic Inflammation and Infection·Roomasa ChannaQuan Dong Nguyen
Mar 28, 2012·Current Opinion in Ophthalmology·Ian Y WongWico W Lai

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