PMID: 16523163Mar 9, 2006Paper

Fundus flavimaculatus and choroidal neovascularization

Journal français d'ophtalmologie
Dominique PawlakGisele Soubrane

Abstract

Fundus flavimaculatus is an aspect of Stargardt disease, which is characterized by juvenile onset, rapidly progressive deterioration, and poor visual outcome due to atrophic areas or flecks. Recently, a late-onset form has been described, on the borderline with AMD. However, choroidal neovascular complications are not frequent and rarely described in Stargardt's disease. Late discovery of FFM in a patient over 50 years old. During her follow-up, she presented a decrease in visual acuity due to juxtafoveal choroidal neovascularization. In spite of laser treatment, a retrofoveal recurrence appeared, which was treated with perifoveal laser. Confusion between AMD and a late-onset Stargardt may occur because of their many clinical similarities. The population and the fundus results can be similar to AMD and an examiner may be confused. In the literature, choroidal neovascular complications appear in patients over 50 years of age who may suffer from AMD. In fundus flavimaculatus, pigmentary epithelium alterations are due to progressive lipoproteic scrap storage that predisposes to Bruch's membrane rupture and choroidal neovascularization. This physiopathology resembles the that of AMD. Choroidal neovascular complications are possible...Continue Reading

References

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Citations

Dec 3, 2013·Progress in Retinal and Eye Research·Nicole T M SaksensCarel B Hoyng
Jul 26, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Joshua CohenChristine N Kay
Jul 26, 2011·European Journal of Ophthalmology·Maurizio Battaglia ParodiFrancesco M Bandello
Mar 6, 2015·The British Journal of Ophthalmology·Maurizio Battaglia ParodiFrancesco Bandello
Oct 17, 2019·Investigative Ophthalmology & Visual Science·Esmee H RunhartCarel B Hoyng
Apr 29, 2020·Current Drug Targets·Maurizio Battaglia ParodiStefano Da Pozzo

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