Fungal extracellular vesicles: modulating host-pathogen interactions by both the fungus and the host

Microbes and Infection
D Zamith-MirandaJ D Nosanchuk

Abstract

The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell-cell communication. In regards to host-pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host-pathogen interactions.

Citations

Aug 7, 2018·Molecular Microbiology·Marcio L Rodrigues, Arturo Casadevall
Nov 7, 2019·MSphere·Mateus Silveira FreitasFausto Almeida
Jun 20, 2020·Cellular Microbiology·Gabriele VargasLeonardo Nimrichter
Oct 26, 2018·Frontiers in Immunology·Tamires Aparecida BitencourtFausto Almeida
Jul 19, 2019·The Journal of Experimental Biology·Colleen A MangoldDavid P Hughes
Aug 8, 2020·Frontiers in Cellular and Infection Microbiology·Juliana RizzoGuilhem Janbon
May 5, 2020·Journal of Extracellular Vesicles·Charlotte S DawsonMarilyn A Anderson
May 8, 2020·MSphere·Verônica S BrauerFausto Almeida
Sep 20, 2020·Pathogens·Haroldo C de OliveiraMarcio L Rodrigues
Nov 2, 2019·Cells·Danielle J LeeThomas Haselhorst
Mar 24, 2020·Fungal Genetics and Biology : FG & B·Fabiana Freire M OliveiraLarissa Fernandes
Apr 27, 2021·Environmental Science. Processes & Impacts·Hannah M McMillanChristine Ogilvie Hendren

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