PMID: 6398126Oct 1, 1984Paper

Fungal infections in hematological neoplastic disease: the possibility of chemoprophylaxis

Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
R FanciG Gargani

Abstract

Immunoelectrosmophoresis (IEOP) was used to detect antigens of Candida albicans in the sera of 90 patients with hemolymphoblastosis. A higher percentage of sensitive results occurred in patients with acute myeloid leukemia; moreover, most of the serologically positive patients showed severe leukopenia and neutropenia (WBC less than 1000/microliter; neutrophils less than 200/microliter). According to the results of IEOP assays, a prophylactic treatment with standard dosages of amphotericin B or myconazole was instituted in positive cases. Treatment schedules were randomized in order to assess the effect of each drug. The therapy resulted in serological negativity in 60% of the patients treated with amphotericin B and 57% of those who were given myconazole.

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