PMID: 8589469Oct 1, 1995Paper

Fungal infections in left ventricular assist device recipients. Incidence, prophylaxis, and treatment

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
D J GoldsteinM C Oz

Abstract

The authors reviewed the charts of 26 recipients of a left ventricular assist device to determine the incidence of fungal infections and the clinical course of these patients. Nine patients (35%) had positive fungal cultures. Of these, six had clinical infections and three were colonized asymptomatically. Three of the six infected patients (including one with mediastinal sepsis and another requiring left ventricular assist device replacement for intractable fungemia) underwent orthotopic heart transplantation after successful therapy. Of the remaining three, one died of a thromboembolic stroke (probably septic in nature), one died secondary to driveline rupture, and the third succumbed to culture-negative sepsis. Two of the colonized patients underwent transplantation, and the third succumbed to perioperative right sided circulatory failure and hypoxia. Positive fungal cultures were a common finding in our series. Because of a significant incidence of fungal infection-related morbidity, the authors revised their pre operative and post operative protocol to include: 1) 2 weeks of fluconazole therapy (200 mg intravenously daily) for patients receiving broad spectrum antibiotics and for those with evidence of preoperative fungal c...Continue Reading

Citations

Mar 10, 2001·The Annals of Thoracic Surgery·F NurozlerY Naka
Sep 4, 1999·The Annals of Thoracic Surgery·W L HolmanJ K Kirklin
Nov 15, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David H McKennaSoon Park
Dec 1, 1999·AACN Clinical Issues·T Duke, J Perna
Feb 2, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Saima AslamRabih O Darouiche
Mar 5, 2008·The Pediatric Infectious Disease Journal·Louis de RepentignySuzanne Vobecky
Sep 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John M StulakFrancis D Pagani
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jun 25, 2003·The Annals of Thoracic Surgery·William L HolmanJames K Kirklin
Aug 1, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A KornbergerA Beiras-Fernandez
Oct 6, 1997·The Annals of Thoracic Surgery·J L SkinnerW L Holman
Dec 8, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S P GoldbergW L Holman
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J StrahilevitzD Engelhard
Nov 20, 1998·The New England Journal of Medicine·D J GoldsteinE A Rose

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