Fungal inhibitors of proteolytic enzymes: classification, properties, possible biological roles, and perspectives for practical use

Biochimie
Yakov E DunaevskyMikhail A Belozersky

Abstract

Peptidase inhibitors are ubiquitous regulatory proteins controlling catalytic activity of proteolytic enzymes. Interest in these proteins increased substantially after it became clear that they can be used for therapy of various important diseases including cancer, malaria, and autoimmune and neurodegenerative diseases. In this review we summarize available data on peptidase inhibitors from fungi, emphasizing their properties, biological role, and possible practical applications of these proteins in the future. A number of fungal peptidase inhibitors with unique structure and specificity of action have no sequence homology with other classes of peptidase inhibitors, thus representing new and specific candidates for therapeutic use. The main classifications of inhibitors in current use are considered. Available data on structure, mechanisms and conditions of action, and diversity of functions of peptidase inhibitors of fungi are analyzed. It is mentioned that on one side the unique properties of some inhibitors can be used for selective inhibition of peptidases responsible for initiation and development of pathogenic processes. On the other side, general inhibitory activity of other inhibitors towards peptidases of various catal...Continue Reading

References

Sep 1, 1974·European Journal of Biochemistry·T SahekiH Holzer
Jan 1, 1980·Annual Review of Biochemistry·M Laskowski, I Kato
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A JongsmaW J Stiekema
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·P SlusarewiczW T Wickner
Jul 31, 1998·Insect Biochemistry and Molecular Biology·C GirardL Jouanin
Mar 13, 2001·Biochemical and Biophysical Research Communications·S KojimaK Miura
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M McNeilD W Warnock
Dec 12, 2002·Chemical Reviews·James C PowersKaren Ellis James
May 3, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·B OppertK J Kramer
May 17, 2003·Critical Reviews in Biochemistry and Molecular Biology·Chandravanu DashMala Rao
Jul 23, 2003·Mini Reviews in Medicinal Chemistry·T Schirmeister, A Klockow
Jan 7, 2004·The Biochemical Journal·Neil D RawlingsAlan J Barrett
Apr 21, 2004·Journal of Medical Microbiology·Yoshiyuki OkumuraToshiaki Nikai
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·G Dubin
May 25, 2006·Drug Development and Industrial Pharmacy·Bojan DoljakMarina Zacchigna
Aug 22, 2006·Current Medicinal Chemistry·R Frlan, S Gobec
Aug 31, 2006·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Yoshiyuki OkumuraToshiaki Nikai
Jan 16, 2007·Protein Expression and Purification·Jerica SaboticJoze Brzin
Feb 9, 2007·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Yoshiyuki OkumuraKei-ichi Uchiya
May 3, 2008·The Plant Cell·Mohammed ShababRenier A L van der Hoorn
May 3, 2008·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Yoshiyuki OkumuraToshiaki Nikai
Jun 10, 2008·Mycological Research·Peter J M SteenbakkersHuub J M Op den Camp
Jun 14, 2008·Current Opinion in Plant Biology·Johana C Misas-Villamil, Renier A L van der Hoorn
Jun 21, 2008·Journal of Medical Microbiology·Yoshiyuki OkumuraToshiaki Nikai
Jul 4, 2008·The Journal of Clinical Investigation·Fabrizio TrincheseOttavio Arancio
Jul 31, 2008·Prikladnaia biokhimiia i mikrobiologiia·V V Mosolov, T A Valueva
Aug 26, 2009·Fitoterapia·Francesca CateniGiuseppe Procida
Oct 23, 2009·The Journal of Biological Chemistry·Miha RenkoDusan Turk
Jun 29, 2010·Journal of Experimental Botany·Urte SchlüterDominique Michaud

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Citations

Nov 2, 2015·Applied Microbiology and Biotechnology·Jerica SabotičMarkus Künzler
Jul 14, 2016·Journal of Basic Microbiology·Rafał SeredyńskiJan Gutowicz
Apr 6, 2004·FEMS Microbiology Letters·András SzekeresLászló Manczinger
Aug 31, 2020·Current Microbiology·Andréa Patrícia da Silva Pomposo BastosSilvana Marcussi
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Habibu AliyuKatrin Ochsenreither
Jan 23, 2021·International Journal of Molecular Sciences·Mohamed Amine JmelMichalis Kotsyfakis
Oct 15, 2021·Applied Biochemistry and Biotechnology·Prashant S AryaVikram H Raval

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