Fungal Interface Keratitis After Descemet Membrane Endothelial Keratoplasty

Cornea
Victor A AugustinTheofilos Tourtas

Abstract

To evaluate the incidence, clinical course, and management of fungal interface keratitis (IK) after Descemet membrane endothelial keratoplasty (DMEK). This is a single-center retrospective observational case series of 3950 eyes undergoing DMEK. Six eyes with fungal IK were detected and analyzed. Analysis included graft storage condition, incidence of fungal IK, identification of the pathogenic agent, topical/systemic and surgical treatment regimen, and best-corrected visual acuity. Fungal IK after DMEK occurred in 6 of 3950 cases (0.15%). Corneal grafts were either stored in Optisol-GS (n = 4) or in organ culture (n = 2). In all cases, Candida species were isolated (Candida tropicalis, Candida albicans, Candida orthopsilosis, and Candida guilliermondii). Four eyes developed fungal IK during the early postoperative period (3-5 d) and 2 eyes later at 16 to 42 days after surgery. All patients received topical and systemic antifungal treatment and intracameral application of antifungal agents. In the case of an early infection, graft removal was performed in 3 of 4 patients. Late infections were eradicated without graft exchange. Recurrence of fungal infection was observed in 1 case after early IK and in both cases after late IK. F...Continue Reading

References

Nov 15, 2006·Cornea·Mark S Gorovoy
Nov 15, 2006·Cornea·Gerrit R J MellesJacqueline van der Wees
Mar 9, 2012·American Journal of Ophthalmology·Theofilos TourtasFriedrich E Kruse
May 3, 2014·JAMA Ophthalmology·Noelle LayerBennie H Jeng
May 30, 2014·Current Opinion in Ophthalmology·Friedrich E KruseTheofilos Tourtas
Aug 2, 2017·The Open Ophthalmology Journal·Matthew Thompson, David Carli
Oct 5, 2017·Cornea·Elmer Y Tu, Parag A Majmudar

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Citations

Dec 20, 2018·The British Journal of Ophthalmology·Nicola LauStephen J Tuft
Jul 13, 2020·Archivos de la Sociedad Española de Oftalmología·Á Sánchez-VentosaA Villarrubia Cuadrado
Oct 24, 2020·International Ophthalmology Clinics·Allister GibbonsNicolas A Yannuzzi
Nov 13, 2020·Case Reports in Ophthalmological Medicine·Ana MartaLuís Oliveira
Mar 6, 2021·Medical Mycology Case Reports·Alexander M AldejohannDaniel Kampik
Jan 2, 2020·Ophthalmology·Allister GibbonsSonia H Yoo
May 5, 2021·The British Journal of Ophthalmology·Shilpa DasSujata Das
Dec 24, 2021·Indian Journal of Ophthalmology·Sujata DasSavitri Sharma

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