Fungal mediated innate immune memory, what have we learned?

Seminars in Cell & Developmental Biology
Jessica Quintin

Abstract

The binary classification of mammalian immune memory is now obsolete. Innate immune cells carry memory characteristics. The overall capacity of innate immune cells to remember and alter their responses is referred as innate immune memory and the induction of a non-specific memory resulting in an enhanced immune status is termed "trained immunity". Historically, trained immunity was first described as triggered by the human fungal pathogen Candida albicans. Since, numerous studies have accumulated and deciphered the main characteristics of trained immunity mediated by fungi and fungal components. This review aims at presenting the newly described aspect of memory in innate immunity with an emphasis on the historically fungal mediated one, covering the known molecular mechanisms associated with training. In addition, the review uncovers the numerous non-specific effect that β-glucans trigger in the context of infectious diseases and septicaemia, inflammatory diseases and cancer.

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Citations

Jul 26, 2018·Journal of Cancer Research and Clinical Oncology·Yiran ZhangLijuan Zhang
Jun 20, 2019·Frontiers in Immunology·Giselle M BoukhaledConnie M Krawczyk
Feb 21, 2021·International Journal of Biological Macromolecules·Jéssica WoukAneli M Barbosa-Dekker
May 1, 2021·Nutrients·Shafaque RahmanSigrid E M Heinsbroek
Nov 7, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cody L StothersEdward R Sherwood

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