Fungal mycelia show lag time before re-growth on endogenous carbon

Biotechnology and Bioengineering
Judith K PollackMark R Marten

Abstract

Nutrient starvation is a common occurrence for filamentous fungi. To better understand the effects of starvation, we used a parallel plate flow chamber to study individual fungal mycelia when subjected to a step change in glucose concentration. We report the presence of a finite "lag time" in starved mycelia during which they ceased to grow/extend while switching from growth on exogenous carbon to re-growth on endogenous carbon. This lag time precedes other morphological or physiological changes such as change in growth rate (50-70% reduction), vacuolation (up to 16%), and decreased hyphal diameter (almost 50% reduction). Data suggests that during lag time, vacuolar degradation produces sufficient endogenous carbon to support survival and restart hyphal extension. Lag time is inversely related to the size of the mycelium at the time of starvation, which suggests a critical flow of endogenous carbon to the apical tip. We present a mathematical model consistent with our experimental observations that relate lag time, area, and flow of endogenous carbon.

References

Mar 1, 1974·Journal of General Microbiology·A P Trinci
Dec 27, 1982·Mycopathologia·M I Perez-LeblicR Lahoz
May 14, 1998·Microbiology·P W CoxC R Thomas
Apr 1, 1999·Biotechnology and Bioengineering·A SpohrJ Villadsen
Apr 1, 1999·Biotechnology and Bioengineering·T ChristiansenJ Nielsen
Nov 7, 1999·Biotechnology and Bioengineering·S P BockingA P Trinci
Jan 6, 2000·Biotechnology and Bioengineering·C MüllerJ Nielsen
Feb 13, 2001·Journal of Theoretical Biology·G Gierz, S Bartnicki-Garcia
May 19, 2001·Canadian Journal of Microbiology·M McIntyreB McNeil
Apr 18, 2002·Critical Reviews in Biotechnology·Stewart WhiteBrian McNeil
Aug 6, 2002·Current Opinion in Microbiology·Dominique Sanglard
Aug 5, 2003·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Jose L Adrio, Arnold L Demain
Sep 2, 2003·Fungal Genetics and Biology : FG & B·Jens Dynesen, Jens Nielsen
Sep 1, 2005·Applied Microbiology and Biotechnology·Martin B HaackAnna Eliasson Lantz
Jan 30, 2007·Fungal Genetics and Biology : FG & B·Yonghyun KimMark R Marten
Jan 5, 1992·Biotechnology and Bioengineering·H YangE D Gilles

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Citations

May 24, 2013·Applied Microbiology and Biotechnology·Benjamin M NitscheArthur F J Ram
Oct 1, 2013·Applied Microbiology and Biotechnology·Oliver Voigt, Stefanie Pöggeler
Oct 28, 2015·Research in Microbiology·María Camila MoralesMargarita Carú
May 28, 2011·Biotechnology and Bioengineering·Yonghyun KimMark R Marten
Aug 3, 2011·Biotechnology and Bioengineering·Lasse PedersenJette Thykaer
Aug 19, 2015·Micron : the International Research and Review Journal for Microscopy·Peixin HeWei Liu
May 7, 2009·FEMS Microbiology Reviews·Amir SharonIdo Hatam
Jun 14, 2020·Archives of Microbiology·C CamposF J Fernández
Nov 5, 2019·Frontiers in Microbiology·Pamela VrablWolfgang Burgstaller

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