Fungal Pigments and Their Roles Associated with Human Health

Journal of Fungi
Lan Lin, Jianping Xu

Abstract

Fungi can produce myriad secondary metabolites, including pigments. Some of these pigments play a positive role in human welfare while others are detrimental. This paper reviews the types and biosynthesis of fungal pigments, their relevance to human health, including their interactions with host immunity, and recent progresses in their structure-activity relationships. Fungal pigments are grouped into carotenoids, melanin, polyketides, and azaphilones, etc. These pigments are phylogenetically broadly distributed. While the biosynthetic pathways for some fungal pigments are known, the majority remain to be elucidated. Understanding the genes and metabolic pathways involved in fungal pigment synthesis is essential to genetically manipulate the production of both the types and quantities of specific pigments. A variety of fungal pigments have shown wide-spectrum biological activities, including promising pharmacophores/lead molecules to be developed into health-promoting drugs to treat cancers, cardiovascular disorders, infectious diseases, Alzheimer's diseases, and so on. In addition, the mechanistic elucidation of the interaction of fungal pigments with the host immune system provides valuable clues for fighting fungal infection...Continue Reading

References

Jul 1, 1992·The Journal of Experimental Medicine·A GarbeU Hämmerling
Jan 1, 1988·Current Topics in Medical Mycology·M H Wheeler, A A Bell
Nov 1, 1971·Journal of Pharmaceutical Sciences·G SullivanR F Lenehan
Jun 1, 1995·Photochemistry and Photobiology·Z Diwu
Dec 31, 1993·Annals of the New York Academy of Sciences·M M Mathews-Roth
Aug 1, 1996·The Journal of Experimental Medicine·S D SalasP R Williamson
May 27, 1999·The Journal of Antibiotics·H TomodaS Omura
Dec 3, 1999·British Journal of Clinical Pharmacology·B M McGleenonA P Passmore
Mar 4, 2000·Applied and Environmental Microbiology·H HajjajJ François
May 19, 2000·Infection and Immunity·R Romero-MartinezH Torres-Guerrero
Jul 18, 2001·Journal of the American Chemical Society·P SpitellerW Steglich
Sep 22, 2001·Food Additives and Contaminants·L MartínkováV Prikrylová
Feb 12, 2002·Critical Reviews in Food Science and Nutrition·Nelson DuránElisa Esposito
Nov 9, 2002·Experimental Biology and Medicine·Tiina RissanenJukka T Salonen
Aug 20, 2003·The Journal of Experimental Medicine·Frédéric GeissmannMichel Dy
Jan 1, 2004·Natural Product Reports·Melvyn Gill
Jan 6, 2004·The Journal of Nutrition·Boon P Chew, Jean Soon Park
Mar 9, 2004·Progress in Lipid Research·Paul D Fraser, Peter M Bramley
Apr 1, 1994·Natural Product Reports·P M Dewick
Aug 25, 2004·Archives of Biochemistry and Biophysics·Ali El-AgameyAndrew J Young
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Nan-Wei SuChen-Ying Ho
Apr 16, 2005·Current Opinion in Biotechnology·Sameer A S MapariUlf Thrane
Jun 30, 2005·Journal of the American Chemical Society·Jianglong ZhuJohn A Porco
Aug 23, 2005·Infection and Immunity·Rachael Morris-JonesAndrew J Hamilton
Oct 8, 2005·FEMS Microbiology Letters·Joong-Hyeop ParkJin-Cheol Kim
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Dang Ngoc QuangYoshinori Asakawa
Jul 1, 1996·Applied and Environmental Microbiology·J E Hallsworth, N Magan
Mar 22, 2006·Microbiology·Thomas B Rasmussen, Michael Givskov
May 24, 2006·Journal of Biotechnology·Julia Schümann, Christian Hertweck
Jun 15, 2006·Chemical Reviews·Ji-Kai Liu
Aug 11, 2006·Biotechnology Letters·C ChidanandaA P Sattur
Sep 14, 2006·Journal of Agricultural and Food Chemistry·Sameer A S MapariUlf Thrane

❮ Previous
Next ❯

Citations

Apr 10, 2021·Critical Reviews in Biotechnology·Haritha Meruvu, Júlio César Dos Santos
Jul 3, 2021·Journal of Fungi·Ellie Rose MattoonArturo Casadevall

❮ Previous
Next ❯

Methods Mentioned

BETA
electron paramagnetic resonance

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
J BARON
Laboratory Investigation; a Journal of Technical Methods and Pathology
Pigment Cell & Melanoma Research
Nicholas P EdwardsRoy A Wogelius
© 2021 Meta ULC. All rights reserved