Abstract
Angiogenesis is crucial to tumor growth and metastasis, and interruption of this process is a prime avenue for therapeutic intervention of tumor proliferation. The present study has made use of the S180 tumor-bearing mouse model to investigate the polysaccharopeptide, PSP, isolated from the edible mushroom Coriolus versicolor, a herbal medicine known for its anti-angiogenesis properties. Quantitative analysis of microcorrosion casting of the tumor tissue showed more angiogenic features such as dense sinusoids and hot spots, in control (untreated) than in PSP-treated animals. Immunostaining of tumor tissues with antibody against the endothelial cell marker (Factor VIII) demonstrated a positive correlation in that both the vascular density and tumor weight were lower in mice treated with PSP. Morphometric analysis of corrosion casts revealed that, even though the total amount of new vessel production was reduced, the basic tumor type-specific vascular architecture was retained. However, the expression of vascular endothelial cell growth factor (VEGF) in these tumors was suppressed. In conclusion, anti-angiogenesis should be one of the pathways through which PSP mediated its anti-tumor activity.
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Jan 1, 1991·Pharmacology & Therapeutics·R AuerbachI Polakowski
Dec 1, 1990·The Journal of Experimental Medicine·M ClaussD Stern
Dec 15, 1994·Biochemical and Biophysical Research Communications·M IizukaH Moriya
Feb 1, 1995·Trends in Pharmacological Sciences·T P FanR Bicknell
Jan 1, 1995·Nature Medicine·J Folkman
Jan 1, 1995·Life Sciences·H X WangS T Chang
Sep 1, 1993·Immunopharmacology·W K LiuK W Tsui
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·G KériA Ullrich
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H X WangS T Chang
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Jun 1, 1997·The Journal of Urology·F A FerrerD L Kreutzer
May 1, 1997·Kidney International·P Pintavorn, B J Ballermann
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R YamaguchiM Kojiro
Jun 9, 1999·British Journal of Cancer·M A KonerdingJ Denekamp
Sep 1, 1999·Kidney International·N Ferrara
Citations
Oct 16, 2009·Applied Microbiology and Biotechnology·Iris LaviBetty Schwartz
Aug 19, 2011·Journal of Agricultural and Food Chemistry·Sung Phil KimMendel Friedman
Jul 15, 2009·Acta Pharmacologica Sinica·Jiao QianJian-guo Liu
Jan 6, 2012·Journal of Medicinal Food·Sang Chul JeongGerald Pang
Jul 21, 2005·Mediators of Inflammation·Cristina LullHuub F J Savelkoul
Nov 23, 2010·Nutrition Journal·Jane E RambergRobert A Sinnott
Feb 3, 2009·Biological & Pharmaceutical Bulletin·Kyosuke YamamotoNariaki Matsuura
Apr 23, 2010·The Tohoku Journal of Experimental Medicine·Dalia AkramieneEgidijus Kevelaitis
Mar 13, 2014·Carbohydrate Polymers·Sourav K MukhopadhyaySatyahari Dey
Aug 14, 2012·Microscopy Research and Technique·Maristela Soares Swerts PereiraMarcos A Rossi
Jun 27, 2014·Mediators of Inflammation·Yan ZhouXiangdong Gao
Aug 4, 2011·Bioscience Reports·Ning LiFang Liu
Jun 21, 2015·Chemico-biological Interactions·Daoyuan RenYan Zhao
Mar 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lj HarhajiS Stosić-Grujicić
Nov 28, 2013·Carbohydrate Polymers·Zhongwei WuXiaoxiong Zeng
Jul 28, 2005·FEMS Microbiology Letters·Shih Chung ChenDanny Ling Wang
Dec 2, 2010·Natural Product Reports·Barbara La FerlaFrancesco Nicotra
Jan 18, 2011·Natural Product Reports·Laura BarsantiPaolo Gualtieri
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wing-Fu LaiGuping Tang
Apr 11, 2020·Applied Microbiology and Biotechnology·Jack Ho WongLixin Xia
May 30, 2020·Biomedicines·Solomon Habtemariam
Oct 5, 2019·Carbohydrate Polymers·Hye Ji LeeTae-Il Kim
Aug 8, 2006·International Journal of Biological Macromolecules·Haiping Li, Shuo Wang