Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization

The Journal of Antibiotics
Yukio KoizumiSatoshi Omura

Abstract

A fungal alkaloid fungerin was found to arrest the cell cycle of Jurkat cells at the G2/M phase, then to induce apoptosis. Immunoblotting showed that fungerin led to hyperphosphorylation for Cdc25C and dephosphorylation of Cdc2, indicating that the compound arrests the cell cycle at the M phase. Moreover, fungerin inhibited the polymerization of microtubule proteins in vitro. It was concluded that fungerin arrests the cell cycle at the M phase through inhibition of microtubule polymerization.

Citations

Aug 14, 2020·Natural Product Reports·Mingzhu LiHuawei Zhang
Jun 3, 2006·Natural Product Reports·Zhong Jin
Aug 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luca PiemonteseMichele Solfrizzo
Mar 2, 2006·The Journal of Antibiotics·Ryuji UchidaSatoshi Omura

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