Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M A PfallerR P Wenzel

Abstract

Cilofungin (LY121019) was shown to have potent fungicidal activity against clinical isolates of Candida albicans and Candida tropicalis but not Candida parapsilosis. Fungicidal activity was evident against both replicating and non-replicating Candida albicans and was progressive over the first 12 h of incubation. The combination of cilofungin (LY121019) with anticapsin but not with amphotericin B, ketoconazole or 5-fluorocytosine resulted in synergistic fungicidal activity. This compound warrants further investigation of its safety and efficacy in the treatment of Candida infections.

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Citations

Jul 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K R SmithC G Cobbs
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·P M Bennett
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·L AngiolellaA Cassone
Nov 4, 2000·Expert Opinion on Investigational Drugs·A J De Lucca
Sep 18, 2004·The Journal of Antimicrobial Chemotherapy·Manuel Cuenca-Estrella
Dec 31, 1998·Antimicrobial Agents and Chemotherapy·A J De Lucca, T J Walsh
Apr 8, 2020·Frontiers in Cellular and Infection Microbiology·Miguel Fernández de UllivarriPaul D Cotter

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